Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186298506> ?p ?o ?g. }
- W3186298506 endingPage "734" @default.
- W3186298506 startingPage "734" @default.
- W3186298506 abstract "Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARS-Cov-2 pandemic progresses. PCR remains the standard benchmark for initial diagnosis of COVID-19 infection, while advances in immunological profiling are guiding clinical treatment. The SARS-Cov-2 virus has undergone multiple mutations since its emergence in 2019, resulting in changes in virulence that have impacted on disease severity globally. The emergence of more virulent variants of SARS-Cov-2 remains challenging for effective disease control during this pandemic. Major variants identified to date include B.1.1.7, B.1.351; P.1; B.1.617.2; B.1.427; P.2; P.3; B.1.525; and C.37. Globally, large unvaccinated populations increase the risk of more and more variants arising. With successive waves of COVID-19 emerging, strategies that mitigate against community transmission need to be implemented, including increased vaccination coverage. For treatment, convalescent plasma therapy, successfully deployed during recent Ebola outbreaks and for H1N1 influenza, can increase survival rates and improve host responses to viral challenge. Convalescent plasma is rich with cytokines (IL-1β, IL-2, IL-6, IL-17, and IL-8), CCL2, and TNFα, neutralizing antibodies, and clotting factors essential for the management of SARS-CoV-2 infection. Clinical trials can inform and guide treatment policy, leading to mainstream adoption of convalescent therapy. This review examines the limited number of clinical trials published, to date that have deployed this therapy and explores clinical trials in progress for the treatment of COVID-19." @default.
- W3186298506 created "2021-08-02" @default.
- W3186298506 creator A5008770208 @default.
- W3186298506 creator A5012840450 @default.
- W3186298506 creator A5013567602 @default.
- W3186298506 creator A5015358714 @default.
- W3186298506 creator A5019363285 @default.
- W3186298506 creator A5041286362 @default.
- W3186298506 creator A5041886121 @default.
- W3186298506 creator A5044212829 @default.
- W3186298506 creator A5046078768 @default.
- W3186298506 creator A5051604725 @default.
- W3186298506 creator A5059634792 @default.
- W3186298506 creator A5060621248 @default.
- W3186298506 creator A5061490879 @default.
- W3186298506 creator A5064062758 @default.
- W3186298506 creator A5066619473 @default.
- W3186298506 creator A5069862202 @default.
- W3186298506 creator A5073881924 @default.
- W3186298506 creator A5082754542 @default.
- W3186298506 creator A5085954030 @default.
- W3186298506 creator A5088140680 @default.
- W3186298506 creator A5090665178 @default.
- W3186298506 date "2021-07-23" @default.
- W3186298506 modified "2023-10-10" @default.
- W3186298506 title "The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections" @default.
- W3186298506 cites W1481410803 @default.
- W3186298506 cites W1485932749 @default.
- W3186298506 cites W15133725 @default.
- W3186298506 cites W1540635906 @default.
- W3186298506 cites W1603558825 @default.
- W3186298506 cites W1814034318 @default.
- W3186298506 cites W1862461292 @default.
- W3186298506 cites W1940034329 @default.
- W3186298506 cites W1964402677 @default.
- W3186298506 cites W1975075656 @default.
- W3186298506 cites W1977020956 @default.
- W3186298506 cites W1978380144 @default.
- W3186298506 cites W1979121754 @default.
- W3186298506 cites W1981450536 @default.
- W3186298506 cites W1986050160 @default.
- W3186298506 cites W1987080322 @default.
- W3186298506 cites W1996791478 @default.
- W3186298506 cites W2001010891 @default.
- W3186298506 cites W2006539971 @default.
- W3186298506 cites W2028961398 @default.
- W3186298506 cites W2033589094 @default.
- W3186298506 cites W2035925204 @default.
- W3186298506 cites W2036040746 @default.
- W3186298506 cites W2051103056 @default.
- W3186298506 cites W2057439500 @default.
- W3186298506 cites W2057493194 @default.
- W3186298506 cites W2065630216 @default.
- W3186298506 cites W2072075382 @default.
- W3186298506 cites W2073848181 @default.
- W3186298506 cites W2075351796 @default.
- W3186298506 cites W2081315886 @default.
- W3186298506 cites W2082589219 @default.
- W3186298506 cites W2083002978 @default.
- W3186298506 cites W2085978024 @default.
- W3186298506 cites W2092162071 @default.
- W3186298506 cites W2094993149 @default.
- W3186298506 cites W2096238447 @default.
- W3186298506 cites W2096428863 @default.
- W3186298506 cites W2098594805 @default.
- W3186298506 cites W2098836088 @default.
- W3186298506 cites W2100669634 @default.
- W3186298506 cites W2102229939 @default.
- W3186298506 cites W2102286438 @default.
- W3186298506 cites W2102390620 @default.
- W3186298506 cites W2102583346 @default.
- W3186298506 cites W2110235509 @default.
- W3186298506 cites W2116029690 @default.
- W3186298506 cites W2117004115 @default.
- W3186298506 cites W2119544301 @default.
- W3186298506 cites W2121756311 @default.
- W3186298506 cites W2122970539 @default.
- W3186298506 cites W2130063921 @default.
- W3186298506 cites W2133701960 @default.
- W3186298506 cites W2134250657 @default.
- W3186298506 cites W2137140815 @default.
- W3186298506 cites W2137398687 @default.
- W3186298506 cites W2138324310 @default.
- W3186298506 cites W2143500993 @default.
- W3186298506 cites W2148822770 @default.
- W3186298506 cites W2155407787 @default.
- W3186298506 cites W2159857626 @default.
- W3186298506 cites W2161135122 @default.
- W3186298506 cites W2161386023 @default.
- W3186298506 cites W2164310764 @default.
- W3186298506 cites W2166502761 @default.
- W3186298506 cites W2166867592 @default.
- W3186298506 cites W2169492821 @default.
- W3186298506 cites W2232354415 @default.
- W3186298506 cites W2233497605 @default.
- W3186298506 cites W2239741907 @default.
- W3186298506 cites W2306794997 @default.
- W3186298506 cites W2332629841 @default.