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- W3186309078 abstract "Multidrug resistance has dramatically compromised the effectiveness of paclitaxel (PTX). The combined application of PTX and tetrandrine (TET) is a promising avenue in drug-resistant cancer therapy. However, poor drug release and limited intracellular drug accumulation greatly impede this combinational antitumor therapy. To address this problem, we successfully developed a tunable controlled release lipid platform (PT@usNLC) for coordinated drug delivery. The drug release rate of PT@usNLC can be tuned by varying the lipid ratio, which has potential to maximize the therapeutic effects of combined drugs. The TET release rate from PT@usNLC was faster than PTX, which could restore the sensitivity of tumor cells to PTX and exert a synergistic antitumor effect. The appropriate size of PT@usNLC could effectively increase the intracellular drug accumulation. Bothin vitroandin vivostudies revealed that PT@usNLC significantly enhanced the therapeutic effect compared to conventional therapies. This study provides a new strategy for resistant ovarian cancer therapy." @default.
- W3186309078 created "2021-08-02" @default.
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- W3186309078 date "2022-06-09" @default.
- W3186309078 modified "2023-09-27" @default.
- W3186309078 title "Ultra-small lipid carriers with adjustable release profiles for synergistic treatment of drug-resistant ovarian cancer" @default.
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- W3186309078 doi "https://doi.org/10.1088/1361-6528/ac18d6" @default.
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