FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186321632> ?p ?o ?g. }

• W3186321632 abstract "Abstract The Global Diabetes Compact was launched by the World Health Organization in April 2021 with one of its important goals to increase the accessibility and affordability of life-saving medicine—insulin. The rising prevalence of diabetes worldwide is bound to escalate the demand for recombinant insulin therapeutics, and currently, the majority of recombinant insulin therapeutics are produced from E. coli inclusion bodies. Here, a comprehensive review of downstream processing of recombinant human insulin/analogue production from E. coli inclusion bodies is presented . All the critical aspects of downstream processing, starting from proinsulin recovery from inclusion bodies, inclusion body washing, inclusion body solubilization and oxidative sulfitolysis, cyanogen bromide cleavage, buffer exchange, purification by chromatography, pH precipitation and zinc crystallization methods, proinsulin refolding, enzymatic cleavage, and formulation, are explained in this review. Pertinent examples are summarized and the practical aspects of integrating every procedure into a multimodal purification scheme are critically discussed. In the face of increasing global demand for insulin product, there is a pressing need to develop a more efficient and economical production process. The information presented would be insightful to all the manufacturers and stakeholders for the production of human insulins, insulin analogues or biosimilars, as they strive to make further progresses in therapeutic recombinant insulin development and production." @default.
• W3186321632 created "2021-08-02" @default.
• W3186321632 creator A5017861820 @default.
• W3186321632 creator A5081537572 @default.
• W3186321632 date "2021-07-27" @default.
• W3186321632 modified "2023-10-11" @default.
• W3186321632 title "Downstream processing of recombinant human insulin and its analogues production from E. coli inclusion bodies" @default.
• W3186321632 cites W1558317780 @default.
• W3186321632 cites W1586686856 @default.
• W3186321632 cites W1592444421 @default.
• W3186321632 cites W1810520060 @default.
• W3186321632 cites W1892534919 @default.
• W3186321632 cites W1965498546 @default.
• W3186321632 cites W1969835226 @default.
• W3186321632 cites W1975304761 @default.
• W3186321632 cites W1983964367 @default.
• W3186321632 cites W1988676248 @default.
• W3186321632 cites W199150095 @default.
• W3186321632 cites W1992968420 @default.
• W3186321632 cites W2001203736 @default.
• W3186321632 cites W2002739054 @default.
• W3186321632 cites W2004887889 @default.
• W3186321632 cites W2005828847 @default.
• W3186321632 cites W2008943195 @default.
• W3186321632 cites W2009159843 @default.
• W3186321632 cites W2010462701 @default.
• W3186321632 cites W2010685876 @default.
• W3186321632 cites W2012224918 @default.
• W3186321632 cites W2013701819 @default.
• W3186321632 cites W2016907315 @default.
• W3186321632 cites W2018997562 @default.
• W3186321632 cites W2019648185 @default.
• W3186321632 cites W2021944202 @default.
• W3186321632 cites W2024058638 @default.
• W3186321632 cites W2024619133 @default.
• W3186321632 cites W2031323488 @default.
• W3186321632 cites W2037913468 @default.
• W3186321632 cites W2040824780 @default.
• W3186321632 cites W2042839539 @default.
• W3186321632 cites W2045485838 @default.
• W3186321632 cites W2045547097 @default.
• W3186321632 cites W2045944699 @default.
• W3186321632 cites W2054095073 @default.
• W3186321632 cites W2058268622 @default.
• W3186321632 cites W2075004025 @default.
• W3186321632 cites W2082228480 @default.
• W3186321632 cites W2086724651 @default.
• W3186321632 cites W2086934524 @default.
• W3186321632 cites W2090743912 @default.
• W3186321632 cites W2093282943 @default.
• W3186321632 cites W2105330885 @default.
• W3186321632 cites W2113196743 @default.
• W3186321632 cites W2113437454 @default.
• W3186321632 cites W2120498503 @default.
• W3186321632 cites W2132224009 @default.
• W3186321632 cites W2134535829 @default.
• W3186321632 cites W2145492168 @default.
• W3186321632 cites W2153492724 @default.
• W3186321632 cites W2402445451 @default.
• W3186321632 cites W2433895681 @default.
• W3186321632 cites W2502949499 @default.
• W3186321632 cites W2668911228 @default.
• W3186321632 cites W2914120400 @default.
• W3186321632 cites W2982410050 @default.
• W3186321632 cites W2999228034 @default.
• W3186321632 cites W3023332654 @default.
• W3186321632 cites W3024136902 @default.
• W3186321632 cites W4237947797 @default.
• W3186321632 cites W4238532712 @default.
• W3186321632 cites W631921326 @default.
• W3186321632 cites W2307630869 @default.
• W3186321632 doi "https://doi.org/10.1186/s40643-021-00419-w" @default.
• W3186321632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8313369" @default.
• W3186321632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34336550" @default.
• W3186321632 hasPublicationYear "2021" @default.
• W3186321632 type Work @default.
• W3186321632 sameAs 3186321632 @default.
• W3186321632 citedByCount "16" @default.
• W3186321632 countsByYear W31863216322021 @default.
• W3186321632 countsByYear W31863216322022 @default.
• W3186321632 countsByYear W31863216322023 @default.
• W3186321632 crossrefType "journal-article" @default.
• W3186321632 hasAuthorship W3186321632A5017861820 @default.
• W3186321632 hasAuthorship W3186321632A5081537572 @default.
• W3186321632 hasBestOaLocation W31863216321 @default.
• W3186321632 hasConcept C104317684 @default.
• W3186321632 hasConcept C119599485 @default.
• W3186321632 hasConcept C127413603 @default.
• W3186321632 hasConcept C150903083 @default.
• W3186321632 hasConcept C151730666 @default.
• W3186321632 hasConcept C185592680 @default.
• W3186321632 hasConcept C203750385 @default.
• W3186321632 hasConcept C2776865271 @default.
• W3186321632 hasConcept C2779306644 @default.
• W3186321632 hasConcept C2781047461 @default.
• W3186321632 hasConcept C3019948211 @default.
• W3186321632 hasConcept C40767141 @default.
• W3186321632 hasConcept C4916135 @default.
• W3186321632 hasConcept C55493867 @default.
• W3186321632 hasConcept C67568554 @default.

• next