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• W3186331303 abstract "In order to target threatening pathogens, the adaptive immune system performs a continuous reorganization of its lymphocyte repertoire. Following an immune challenge, the B cell repertoire can evolve cells of increased specificity for the encountered strain. This process of affinity maturation generates a memory pool whose diversity and size remain difficult to predict. We assume that the immune system follows a strategy that maximizes the long-term immune coverage and minimizes the short-term metabolic costs associated with affinity maturation. This strategy is defined as an optimal decision process on a finite dimensional phenotypic space, where a pre-existing population of naive cells is sequentially challenged with a neutrally evolving strain. We unveil a trade-off between immune protection against future strains and the necessary reorganization of the repertoire. This plasticity of the repertoire drives the emergence of distinct regimes for the size and diversity of the memory pool, depending on the density of naive cells and on the mutation rate of the strain. The model predicts power-law distributions of clonotype sizes observed in data, and rationalizes antigenic imprinting as a strategy to minimize metabolic costs while keeping good immune protection against future strains." @default.
• W3186331303 created "2021-08-02" @default.
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• W3186331303 date "2021-07-26" @default.
• W3186331303 modified "2023-09-30" @default.
• W3186331303 title "Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints" @default.
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• W3186331303 doi "https://doi.org/10.1101/2021.07.26.453765" @default.
• W3186331303 hasPublicationYear "2021" @default.
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