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- W3186332012 abstract "Abstract Objective. Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis, microangiopathy and immune dysfunction. B cell abnormalities characterized by autoantibody production and polyclonal B cell activation play an important role in the pathogenesis of SSc. We previously identified an expansion of functional and activated circulating T follicular helper (cTfh) cells in SSc patients. The aim of this study was to analyze the frequency of regulatory B (Breg) cell subsets and the correlation with Tfh in SSc patients. Methods. Circulating Breg cells CD24 h iCD38 hi and CD27 + CD24 hi levels and cTfh cells CD4 + CXCR5 + PD1 + were determined by cytometry in 50SSc patients and 32 healthy subjects. Results. The frequency of Breg cells CD24 hi CD38 hi and CD24 hi CD27 + was significantly reduced in patients with SSc as compared to controls (p=0.02 and p<0.001, respectively). In contrast, when examining the CD21 low B cell subset, the frequency was significantly increased in SSc patients compared to healthy controls, (p<0.001). There was no difference in Bregcell levels in patients with diffuse SSc and limited SSc. However, CD24 hi CD27 + Breg cell frequency was significantly decreased in SSc patients with pulmonary arterial hypertension (p=0.014), but not in patients with interstitial lung disease (p=0.058).Furthermore, we observed a negative correlation between cTfh and CD24 hi CD27 + Breg cell levels in SSc patients but not in healthy controls (p=0.02). Conclusions: These results suggest that Breg cell subsets may participate in the regulation of cTfh and disease severity. Decreased CD24 hi CD27 + Breg cell frequencymay contribute to the development of SSc." @default.
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- W3186332012 date "2020-06-15" @default.
- W3186332012 modified "2023-10-18" @default.
- W3186332012 title "Regulatory B Cell Imbalance Correlates With TFH Expansion in Systemic Sclerosis." @default.
- W3186332012 doi "https://doi.org/10.21203/rs.3.rs-34813/v1" @default.
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