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• W3186348096 abstract "The development and differentiation of T cells represents a long and highly coordinated, yet flexible at some points, pathway, along which the sequential and dynamic expressions of different transcriptional factors play prominent roles at multiple steps. The large ZBTB family comprises a diverse group of transcriptional factors, and many of them have emerged as critical factors that regulate the lineage commitment, differentiation and effector function of hematopoietic-derived cells as well as a variety of other developmental events. Within the T-cell lineage, several ZBTB proteins, including ZBTB1, ZBTB17, ZBTB7B (THPOK) and BCL6 (ZBTB27), mainly regulate the development and/or differentiation of conventional CD4/CD8 αβ+ T cells, whereas ZBTB16 (PLZF) is essential for the development and function of innate-like unconventional γδ+ T & invariant NKT cells. Given the critical role of T cells in host defenses against infections/tumors and in the pathogenesis of many inflammatory disorders, we herein summarize the roles of fourteen ZBTB family members in the development, differentiation and effector function of both conventional and unconventional T cells as well as the underlying molecular mechanisms." @default.
• W3186348096 created "2021-08-02" @default.
• W3186348096 creator A5011572319 @default.
• W3186348096 creator A5041545335 @default.
• W3186348096 creator A5055951661 @default.
• W3186348096 creator A5058954885 @default.
• W3186348096 creator A5069864602 @default.
• W3186348096 date "2021-07-19" @default.
• W3186348096 modified "2023-10-16" @default.
• W3186348096 title "ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells" @default.
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