FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186352477> ?p ?o ?g. }

• W3186352477 endingPage "101109" @default.
• W3186352477 startingPage "101109" @default.
• W3186352477 abstract "• A ROS responsive polymer, poly(PMT-co-EGDM), was synthesized and used to construct ROS-scavenging lipid-polymer nanoparticles (PELPNPs). • PELPNPs exhibited a good ROS-scavenging ability both in vitro and in vivo . • PELPNPs could reduce the ROS-induced inflammation and protect neurons against oxidative damages. • PELPNPs reduced the secondary injury and promoted functional recovery in a rat contusion injury model. Suppression of secondary damage following traumatic spinal cord injury (SCI) remains a great challenge in the clinical treatment of acute SCI. To date, the most validated treatment in clinic is the use of antioxidants to reduce reactive oxygen species (ROS)-induced oxidative damage during the secondary injury process. However, clinically available antioxidants, such as methylprednisolone, commonly lead to modest improvement in neurological recovery and yet are accompanied with serious side effects. Herein, we report on the development of lipid-polymer nanoparticles (denoted as PELPNPs) with a high ROS-scavenging ability that effectively eliminated ROS and thus reduced long-term secondary injury in a clinically relevant rat SCI model. In vitro tests demonstrated that PELPNPs could readily scavenge overproduced ROS, reduce inflammation, and protect glial cells and neurons against H 2 O 2 -induced oxidative damage. After intravenous administration, PELPNPs significantly improved the recovery of locomotor function and reduced the lesion area through effective protection of neurons and myelin sheaths. Mechanism studies proved that the superior therapeutic effect of PELPNPs was attributed to their high ROS scavenging and anti-inflammatory abilities. Thus, the proposed ROS-scavenging nanoparticle system shows promise for effective treatment of clinical SCI." @default.
• W3186352477 created "2021-08-02" @default.
• W3186352477 creator A5013362228 @default.
• W3186352477 creator A5022434752 @default.
• W3186352477 creator A5045930233 @default.
• W3186352477 creator A5049761988 @default.
• W3186352477 creator A5071259267 @default.
• W3186352477 creator A5073269968 @default.
• W3186352477 creator A5077971997 @default.
• W3186352477 creator A5078531761 @default.
• W3186352477 date "2021-09-01" @default.
• W3186352477 modified "2023-10-16" @default.
• W3186352477 title "Reactive oxide species-scavenging lipid-polymer nanoparticles for neuroprotection after spinal cord injury" @default.
• W3186352477 cites W1495576061 @default.
• W3186352477 cites W1753183749 @default.
• W3186352477 cites W1861882834 @default.
• W3186352477 cites W1874889006 @default.
• W3186352477 cites W1937650001 @default.
• W3186352477 cites W1970024238 @default.
• W3186352477 cites W1972691957 @default.
• W3186352477 cites W1975495109 @default.
• W3186352477 cites W1975724680 @default.
• W3186352477 cites W1986665549 @default.
• W3186352477 cites W1997146656 @default.
• W3186352477 cites W2000426718 @default.
• W3186352477 cites W2001027721 @default.
• W3186352477 cites W2002120184 @default.
• W3186352477 cites W2010976109 @default.
• W3186352477 cites W2012928251 @default.
• W3186352477 cites W2016780969 @default.
• W3186352477 cites W2029041094 @default.
• W3186352477 cites W2029987677 @default.
• W3186352477 cites W2032956124 @default.
• W3186352477 cites W2033867839 @default.
• W3186352477 cites W2038306701 @default.
• W3186352477 cites W2062071298 @default.
• W3186352477 cites W2068572014 @default.
• W3186352477 cites W2072906068 @default.
• W3186352477 cites W2075288153 @default.
• W3186352477 cites W2076629321 @default.
• W3186352477 cites W2076998548 @default.
• W3186352477 cites W2088536552 @default.
• W3186352477 cites W2093078810 @default.
• W3186352477 cites W2095417387 @default.
• W3186352477 cites W2110536207 @default.
• W3186352477 cites W2114611409 @default.
• W3186352477 cites W2116339604 @default.
• W3186352477 cites W2120636793 @default.
• W3186352477 cites W2130166533 @default.
• W3186352477 cites W2170677280 @default.
• W3186352477 cites W2330379043 @default.
• W3186352477 cites W2346227371 @default.
• W3186352477 cites W2416339173 @default.
• W3186352477 cites W2484283047 @default.
• W3186352477 cites W2724960832 @default.
• W3186352477 cites W2743657963 @default.
• W3186352477 cites W2744892873 @default.
• W3186352477 cites W2760636051 @default.
• W3186352477 cites W2806434442 @default.
• W3186352477 cites W2886853896 @default.
• W3186352477 cites W2888312828 @default.
• W3186352477 cites W2939451604 @default.
• W3186352477 cites W2955372618 @default.
• W3186352477 cites W3002622862 @default.
• W3186352477 doi "https://doi.org/10.1016/j.apmt.2021.101109" @default.
• W3186352477 hasPublicationYear "2021" @default.
• W3186352477 type Work @default.
• W3186352477 sameAs 3186352477 @default.
• W3186352477 citedByCount "17" @default.
• W3186352477 countsByYear W31863524772021 @default.
• W3186352477 countsByYear W31863524772022 @default.
• W3186352477 countsByYear W31863524772023 @default.
• W3186352477 crossrefType "journal-article" @default.
• W3186352477 hasAuthorship W3186352477A5013362228 @default.
• W3186352477 hasAuthorship W3186352477A5022434752 @default.
• W3186352477 hasAuthorship W3186352477A5045930233 @default.
• W3186352477 hasAuthorship W3186352477A5049761988 @default.
• W3186352477 hasAuthorship W3186352477A5071259267 @default.
• W3186352477 hasAuthorship W3186352477A5073269968 @default.
• W3186352477 hasAuthorship W3186352477A5077971997 @default.
• W3186352477 hasAuthorship W3186352477A5078531761 @default.
• W3186352477 hasConcept C118552586 @default.
• W3186352477 hasConcept C185592680 @default.
• W3186352477 hasConcept C203014093 @default.
• W3186352477 hasConcept C25498285 @default.
• W3186352477 hasConcept C2776151105 @default.
• W3186352477 hasConcept C2776914184 @default.
• W3186352477 hasConcept C2778334475 @default.
• W3186352477 hasConcept C2780775167 @default.
• W3186352477 hasConcept C48349386 @default.
• W3186352477 hasConcept C55493867 @default.
• W3186352477 hasConcept C71924100 @default.
• W3186352477 hasConcept C98274493 @default.
• W3186352477 hasConceptScore W3186352477C118552586 @default.
• W3186352477 hasConceptScore W3186352477C185592680 @default.
• W3186352477 hasConceptScore W3186352477C203014093 @default.
• W3186352477 hasConceptScore W3186352477C25498285 @default.
• W3186352477 hasConceptScore W3186352477C2776151105 @default.

• next