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• W3186353037 abstract "Abstract Pathological sensations caused by peripheral painful neuropathy occurring in Type 2 diabetes mellitus (T2DM) are often described as ‘sharp’ and ‘burning’ and are commonly spontaneous in origin. Proposed etiologies implicate dysfunction of nociceptive sensory neurons in dorsal root ganglia (DRG) induced by generation of reactive oxygen species, microvascular defects, and ongoing axonal degeneration and regeneration. To investigate the molecular mechanisms contributing to diabetic pain, DRGs were acquired postmortem from patients who had been experiencing painful diabetic peripheral neuropathy (DPN) and subjected to transcriptome analyses to identify genes contributing to pathological processes and neuropathic pain. DPN occurs in distal extremities resulting in the characteristic “glove and stocking” pattern. Accordingly, the L4 and L5 DRGs, which contain the perikarya of primary afferent neurons innervating the foot, were analyzed from five DPN patients and compared with seven controls. Transcriptom e analyses identified 844 differentially expressed genes. We observed increases in levels of inflammation-associated genes from macrophages in DPN patients that may contribute to increased pain hypersensitivity and, conversely, there were frequent decreases in neuronally-related genes. The elevated inflammatory gene profile and the accompanying downregulation of multiple neuronal genes provide new insights into intraganglionic pathology and mechanisms causing neuropathic pain in DPN patients with T2DM." @default.
• W3186353037 created "2021-08-02" @default.
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• W3186353037 date "2021-07-25" @default.
• W3186353037 modified "2023-09-30" @default.
• W3186353037 title "Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal Loss" @default.
• W3186353037 cites W1579347021 @default.
• W3186353037 cites W1814020593 @default.
• W3186353037 cites W1940688833 @default.
• W3186353037 cites W1976102723 @default.
• W3186353037 cites W198103589 @default.
• W3186353037 cites W1986947132 @default.
• W3186353037 cites W1988768211 @default.
• W3186353037 cites W1996626960 @default.
• W3186353037 cites W1998350079 @default.
• W3186353037 cites W1999195261 @default.
• W3186353037 cites W2005796205 @default.
• W3186353037 cites W2012753407 @default.
• W3186353037 cites W2014189974 @default.
• W3186353037 cites W2014627216 @default.
• W3186353037 cites W2015363965 @default.
• W3186353037 cites W2018707257 @default.
• W3186353037 cites W2028794842 @default.
• W3186353037 cites W2033072655 @default.
• W3186353037 cites W2046998604 @default.
• W3186353037 cites W2048515594 @default.
• W3186353037 cites W2048748542 @default.
• W3186353037 cites W2050629341 @default.
• W3186353037 cites W2054107136 @default.
• W3186353037 cites W2058400593 @default.
• W3186353037 cites W2058791703 @default.
• W3186353037 cites W2060646783 @default.
• W3186353037 cites W2075769621 @default.
• W3186353037 cites W2093217806 @default.
• W3186353037 cites W2096447296 @default.
• W3186353037 cites W2097584797 @default.
• W3186353037 cites W2099366664 @default.
• W3186353037 cites W2112773265 @default.
• W3186353037 cites W2120805022 @default.
• W3186353037 cites W2122750758 @default.
• W3186353037 cites W2126542948 @default.
• W3186353037 cites W2127298360 @default.
• W3186353037 cites W2136328113 @default.
• W3186353037 cites W2147810846 @default.
• W3186353037 cites W2153393011 @default.
• W3186353037 cites W2154507501 @default.
• W3186353037 cites W2154798479 @default.
• W3186353037 cites W2157282220 @default.
• W3186353037 cites W2158277753 @default.
• W3186353037 cites W2159470318 @default.
• W3186353037 cites W2160595023 @default.
• W3186353037 cites W2170872197 @default.
• W3186353037 cites W2179438025 @default.
• W3186353037 cites W2282593836 @default.
• W3186353037 cites W2297634434 @default.
• W3186353037 cites W2323275321 @default.
• W3186353037 cites W2337997790 @default.
• W3186353037 cites W2411826498 @default.
• W3186353037 cites W2460129381 @default.
• W3186353037 cites W2560049155 @default.
• W3186353037 cites W2587680743 @default.
• W3186353037 cites W2597734448 @default.
• W3186353037 cites W2742630504 @default.
• W3186353037 cites W2752407268 @default.
• W3186353037 cites W2761905894 @default.
• W3186353037 cites W2762851710 @default.
• W3186353037 cites W2765874376 @default.
• W3186353037 cites W2790516041 @default.
• W3186353037 cites W2792253966 @default.
• W3186353037 cites W2793396628 @default.
• W3186353037 cites W2794313235 @default.
• W3186353037 cites W2808305854 @default.
• W3186353037 cites W2810328174 @default.
• W3186353037 cites W2888819097 @default.
• W3186353037 cites W2891660975 @default.
• W3186353037 cites W2898190502 @default.
• W3186353037 cites W2912343418 @default.
• W3186353037 cites W2949289016 @default.
• W3186353037 cites W2950162000 @default.
• W3186353037 cites W2950595506 @default.
• W3186353037 cites W2979925777 @default.
• W3186353037 cites W2999016253 @default.
• W3186353037 cites W3000691572 @default.
• W3186353037 cites W3049353672 @default.
• W3186353037 cites W3078481672 @default.
• W3186353037 cites W3128879789 @default.

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