Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186372541> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3186372541 abstract "The mechanisms contributing to the pathogenesis of tremor and/or dysmetria in multiple sclerosis (MS) are poorly understood. Abnormal oscillations within the olivo-cerebello-thalamo-cortical networks are believed to play an important part in tremor aetiology, but could also contribute to intention dysmetria due to disruptions in motor timing. Conversely, delayed central motor conduction times are a common feature of ataxias, but could also contribute to the expression of dysmetria in MS. This study examined the roles of central conduction delays in the manifestation of tremor and/or dysmetria in MS.Twenty-three individuals with MS participated: 8 with no movement disorder, 6 with tremor, 4 with pure dysmetria and 5 with both tremor and dysmetria. Median nerve somatosensory evoked potentials (SEPs), transcranial magnetic stimulation (TMS) over the motor cortex and cervical spine, stretch reflexes were used assess sensory and motor conduction times.Central, but not peripheral, sensory conductions time were significantly delayed in participants with dysmetria, regardless of the presence of tremor. Similarly, the TMS evoked muscles responses and the long-latency component of stretch reflexes were significantly delayed in those with dysmetria, but not pure tremor.Dysmetria in MS is associated with delays in central conduction of sensory or motor pathways, or both, likely leading to disruption of muscle activation timing and terminal oscillations that contribute to dysmetria.The presence of dysmetria in MS is associated with decreased conduction velocities in central sensory and/or motor pathways likely reflects greater demyelination of these axons compared to those with no movement disorder or pure tremor." @default.
- W3186372541 created "2021-08-02" @default.
- W3186372541 creator A5002554963 @default.
- W3186372541 creator A5011319345 @default.
- W3186372541 creator A5038467475 @default.
- W3186372541 creator A5065706732 @default.
- W3186372541 creator A5088964079 @default.
- W3186372541 date "2021-01-01" @default.
- W3186372541 modified "2023-09-27" @default.
- W3186372541 title "Tremor and Dysmetria in Multiple Sclerosis: A Neurophysiological Study" @default.
- W3186372541 cites W2000764921 @default.
- W3186372541 cites W2004265538 @default.
- W3186372541 cites W2005946352 @default.
- W3186372541 cites W2009253229 @default.
- W3186372541 cites W2033002850 @default.
- W3186372541 cites W2033623176 @default.
- W3186372541 cites W2054397243 @default.
- W3186372541 cites W2055556234 @default.
- W3186372541 cites W2113682105 @default.
- W3186372541 cites W2126709817 @default.
- W3186372541 cites W2131455139 @default.
- W3186372541 cites W2133072808 @default.
- W3186372541 cites W2143666197 @default.
- W3186372541 cites W2329203274 @default.
- W3186372541 cites W2333041387 @default.
- W3186372541 cites W2401894048 @default.
- W3186372541 cites W2461511158 @default.
- W3186372541 cites W2945316425 @default.
- W3186372541 doi "https://doi.org/10.5334/tohm.598" @default.
- W3186372541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8323523" @default.
- W3186372541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34395055" @default.
- W3186372541 hasPublicationYear "2021" @default.
- W3186372541 type Work @default.
- W3186372541 sameAs 3186372541 @default.
- W3186372541 citedByCount "4" @default.
- W3186372541 countsByYear W31863725412022 @default.
- W3186372541 countsByYear W31863725412023 @default.
- W3186372541 crossrefType "journal-article" @default.
- W3186372541 hasAuthorship W3186372541A5002554963 @default.
- W3186372541 hasAuthorship W3186372541A5011319345 @default.
- W3186372541 hasAuthorship W3186372541A5038467475 @default.
- W3186372541 hasAuthorship W3186372541A5065706732 @default.
- W3186372541 hasAuthorship W3186372541A5088964079 @default.
- W3186372541 hasBestOaLocation W31863725412 @default.
- W3186372541 hasConcept C15744967 @default.
- W3186372541 hasConcept C169760540 @default.
- W3186372541 hasConcept C179253579 @default.
- W3186372541 hasConcept C24998067 @default.
- W3186372541 hasConcept C2777154897 @default.
- W3186372541 hasConcept C2778970358 @default.
- W3186372541 hasConcept C2779652256 @default.
- W3186372541 hasConcept C2780117969 @default.
- W3186372541 hasConcept C2780294739 @default.
- W3186372541 hasConcept C2780906641 @default.
- W3186372541 hasConcept C522805319 @default.
- W3186372541 hasConcept C71924100 @default.
- W3186372541 hasConceptScore W3186372541C15744967 @default.
- W3186372541 hasConceptScore W3186372541C169760540 @default.
- W3186372541 hasConceptScore W3186372541C179253579 @default.
- W3186372541 hasConceptScore W3186372541C24998067 @default.
- W3186372541 hasConceptScore W3186372541C2777154897 @default.
- W3186372541 hasConceptScore W3186372541C2778970358 @default.
- W3186372541 hasConceptScore W3186372541C2779652256 @default.
- W3186372541 hasConceptScore W3186372541C2780117969 @default.
- W3186372541 hasConceptScore W3186372541C2780294739 @default.
- W3186372541 hasConceptScore W3186372541C2780906641 @default.
- W3186372541 hasConceptScore W3186372541C522805319 @default.
- W3186372541 hasConceptScore W3186372541C71924100 @default.
- W3186372541 hasIssue "1" @default.
- W3186372541 hasLocation W31863725411 @default.
- W3186372541 hasLocation W31863725412 @default.
- W3186372541 hasLocation W31863725413 @default.
- W3186372541 hasLocation W31863725414 @default.
- W3186372541 hasOpenAccess W3186372541 @default.
- W3186372541 hasPrimaryLocation W31863725411 @default.
- W3186372541 hasRelatedWork W1963651478 @default.
- W3186372541 hasRelatedWork W1972453700 @default.
- W3186372541 hasRelatedWork W2002592944 @default.
- W3186372541 hasRelatedWork W2048756309 @default.
- W3186372541 hasRelatedWork W2066813810 @default.
- W3186372541 hasRelatedWork W2160526471 @default.
- W3186372541 hasRelatedWork W2409084129 @default.
- W3186372541 hasRelatedWork W2748952813 @default.
- W3186372541 hasRelatedWork W2899084033 @default.
- W3186372541 hasRelatedWork W3186372541 @default.
- W3186372541 hasVolume "11" @default.
- W3186372541 isParatext "false" @default.
- W3186372541 isRetracted "false" @default.
- W3186372541 magId "3186372541" @default.
- W3186372541 workType "article" @default.