Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186378505> ?p ?o ?g. }
- W3186378505 abstract "Alzheimer disease (AD) is a chronic neurodegenerative disease that accounts for 60–70% of dementia and is the sixth leading cause of death in the United States. The pathogenesis of this debilitating disorder is still not completely understood. New insights into the pathogenesis of AD are needed in order to develop novel pharmacologic approaches. In recent years, numerous studies have shown that insulin resistance plays a significant role in the development of AD. Over 80% of patients with AD have type II diabetes (T2DM) or abnormal serum glucose, suggesting that the pathogenic mechanisms of insulin resistance and AD likely overlap. Insulin resistance increases neuroinflammation, which promotes both amyloid β-protein deposition and aberrant tau phosphorylation. By increasing production of reactive oxygen species, insulin resistance triggers amyloid β-protein accumulation. Oxidative stress associated with insulin resistance also dysregulates glycogen synthase kinase 3-β (GSK-3β), which leads to increased tau phosphorylation. Both insulin and amyloid β-protein are metabolized by insulin degrading enzyme (IDE). Defects in this enzyme are the basis for a strong association between T2DM and AD. This review highlights multiple pathogenic mechanisms induced by insulin resistance that are implicated in AD. Several pharmacologic approaches to AD associated with insulin resistance are presented." @default.
- W3186378505 created "2021-08-02" @default.
- W3186378505 creator A5020545068 @default.
- W3186378505 creator A5063781897 @default.
- W3186378505 creator A5089537823 @default.
- W3186378505 date "2021-07-19" @default.
- W3186378505 modified "2023-10-13" @default.
- W3186378505 title "Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms" @default.
- W3186378505 cites W10297594 @default.
- W3186378505 cites W150222691 @default.
- W3186378505 cites W1543788907 @default.
- W3186378505 cites W1551956363 @default.
- W3186378505 cites W1590561022 @default.
- W3186378505 cites W1621816628 @default.
- W3186378505 cites W1642912455 @default.
- W3186378505 cites W1718410121 @default.
- W3186378505 cites W1729764133 @default.
- W3186378505 cites W1801367656 @default.
- W3186378505 cites W184255001 @default.
- W3186378505 cites W1911139940 @default.
- W3186378505 cites W1953529450 @default.
- W3186378505 cites W1966116864 @default.
- W3186378505 cites W1974371942 @default.
- W3186378505 cites W1976445933 @default.
- W3186378505 cites W1976619844 @default.
- W3186378505 cites W1976856337 @default.
- W3186378505 cites W1978999542 @default.
- W3186378505 cites W1980825524 @default.
- W3186378505 cites W1984044273 @default.
- W3186378505 cites W1984108619 @default.
- W3186378505 cites W1985022327 @default.
- W3186378505 cites W1991237567 @default.
- W3186378505 cites W1992680479 @default.
- W3186378505 cites W1993383247 @default.
- W3186378505 cites W1994735836 @default.
- W3186378505 cites W1995541462 @default.
- W3186378505 cites W1998440070 @default.
- W3186378505 cites W2002302995 @default.
- W3186378505 cites W2004325493 @default.
- W3186378505 cites W2005398842 @default.
- W3186378505 cites W2008702759 @default.
- W3186378505 cites W2011430246 @default.
- W3186378505 cites W2015016479 @default.
- W3186378505 cites W2015594543 @default.
- W3186378505 cites W2020680955 @default.
- W3186378505 cites W2021010709 @default.
- W3186378505 cites W2024731831 @default.
- W3186378505 cites W2026970282 @default.
- W3186378505 cites W2035437757 @default.
- W3186378505 cites W2046140771 @default.
- W3186378505 cites W2047509507 @default.
- W3186378505 cites W2050167321 @default.
- W3186378505 cites W2064483915 @default.
- W3186378505 cites W2067501052 @default.
- W3186378505 cites W2074076323 @default.
- W3186378505 cites W2086679674 @default.
- W3186378505 cites W2088642279 @default.
- W3186378505 cites W2099157718 @default.
- W3186378505 cites W2099271519 @default.
- W3186378505 cites W2102296802 @default.
- W3186378505 cites W2105262354 @default.
- W3186378505 cites W2111765180 @default.
- W3186378505 cites W2129085204 @default.
- W3186378505 cites W2129623936 @default.
- W3186378505 cites W2131760568 @default.
- W3186378505 cites W2133830421 @default.
- W3186378505 cites W2136147886 @default.
- W3186378505 cites W2140607486 @default.
- W3186378505 cites W2141977412 @default.
- W3186378505 cites W2147928374 @default.
- W3186378505 cites W2148020885 @default.
- W3186378505 cites W2153708728 @default.
- W3186378505 cites W2164493941 @default.
- W3186378505 cites W2166853536 @default.
- W3186378505 cites W2167041537 @default.
- W3186378505 cites W2186890399 @default.
- W3186378505 cites W2215490841 @default.
- W3186378505 cites W2219424825 @default.
- W3186378505 cites W2275928777 @default.
- W3186378505 cites W2300480290 @default.
- W3186378505 cites W2329336071 @default.
- W3186378505 cites W2407468727 @default.
- W3186378505 cites W2415922968 @default.
- W3186378505 cites W2427573956 @default.
- W3186378505 cites W2471590266 @default.
- W3186378505 cites W2490099107 @default.
- W3186378505 cites W2498795028 @default.
- W3186378505 cites W2515127987 @default.
- W3186378505 cites W2515408417 @default.
- W3186378505 cites W2517793347 @default.
- W3186378505 cites W2520091477 @default.
- W3186378505 cites W2532720480 @default.
- W3186378505 cites W2539113442 @default.
- W3186378505 cites W2563087870 @default.
- W3186378505 cites W2563631528 @default.
- W3186378505 cites W2582480647 @default.
- W3186378505 cites W2592011417 @default.
- W3186378505 cites W2600906879 @default.
- W3186378505 cites W2607120474 @default.
- W3186378505 cites W2611457672 @default.