Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186379961> ?p ?o ?g. }
- W3186379961 abstract "SUMMARY The development of human organoid model systems has provided new avenues for patient-specific clinical care and disease modeling. However, all organoid systems are missing important cell types that, in the embryo, get incorporated into organ tissues during development. Based on the concept of how embryonic organs are assembled, we developed an organoid assembly approach starting with cells from the three primary germ layers; enteric neuroglial, mesenchymal, and epithelial precursors, all separately derived from human pluripotent stem cells. From these we generated human gastric tissue containing differentiated glands, surrounded by layers of smooth muscle containing functional enteric neurons that controlled contractions of the engineered tissue. We used this highly tractable system to identify essential roles for the enteric nervous system in the growth and regional identity of the gastric epithelium and mesenchyme and for glandular morphogenesis of the antral stomach. This approach of starting with separately-derived germ layer components was applied to building more complex fundic and esophageal tissue, suggesting this as a new paradigm for tissue engineering." @default.
- W3186379961 created "2021-08-02" @default.
- W3186379961 creator A5003793915 @default.
- W3186379961 creator A5005519536 @default.
- W3186379961 creator A5005786535 @default.
- W3186379961 creator A5014752134 @default.
- W3186379961 creator A5022113009 @default.
- W3186379961 creator A5027643261 @default.
- W3186379961 creator A5037288031 @default.
- W3186379961 creator A5038646281 @default.
- W3186379961 creator A5046010698 @default.
- W3186379961 creator A5055095007 @default.
- W3186379961 creator A5061904440 @default.
- W3186379961 creator A5075515149 @default.
- W3186379961 creator A5089184931 @default.
- W3186379961 date "2021-07-16" @default.
- W3186379961 modified "2023-10-17" @default.
- W3186379961 title "Engineering functional human gastrointestinal organoid tissues using the three primary germ layers separately derived from pluripotent stem cells" @default.
- W3186379961 cites W1566099836 @default.
- W3186379961 cites W1889119081 @default.
- W3186379961 cites W1914096163 @default.
- W3186379961 cites W1975774582 @default.
- W3186379961 cites W1976554440 @default.
- W3186379961 cites W1990784939 @default.
- W3186379961 cites W2003095799 @default.
- W3186379961 cites W2005740605 @default.
- W3186379961 cites W2015607265 @default.
- W3186379961 cites W2016606965 @default.
- W3186379961 cites W2017060663 @default.
- W3186379961 cites W2022272931 @default.
- W3186379961 cites W2031190177 @default.
- W3186379961 cites W2031522785 @default.
- W3186379961 cites W2054186703 @default.
- W3186379961 cites W2060770984 @default.
- W3186379961 cites W2070764030 @default.
- W3186379961 cites W2071621760 @default.
- W3186379961 cites W2081128785 @default.
- W3186379961 cites W2088434431 @default.
- W3186379961 cites W2102001184 @default.
- W3186379961 cites W2108740871 @default.
- W3186379961 cites W2113581487 @default.
- W3186379961 cites W2116010045 @default.
- W3186379961 cites W2116508232 @default.
- W3186379961 cites W2119429325 @default.
- W3186379961 cites W2124738850 @default.
- W3186379961 cites W2125112326 @default.
- W3186379961 cites W2129679172 @default.
- W3186379961 cites W2134374915 @default.
- W3186379961 cites W2168678503 @default.
- W3186379961 cites W2171332611 @default.
- W3186379961 cites W2248228111 @default.
- W3186379961 cites W2292396958 @default.
- W3186379961 cites W2413249111 @default.
- W3186379961 cites W2427010667 @default.
- W3186379961 cites W2461230718 @default.
- W3186379961 cites W2479363261 @default.
- W3186379961 cites W2519280441 @default.
- W3186379961 cites W2549963625 @default.
- W3186379961 cites W2568959080 @default.
- W3186379961 cites W2570429698 @default.
- W3186379961 cites W2590236215 @default.
- W3186379961 cites W2596136577 @default.
- W3186379961 cites W2597756992 @default.
- W3186379961 cites W2598789448 @default.
- W3186379961 cites W2614402207 @default.
- W3186379961 cites W2645361946 @default.
- W3186379961 cites W2752734626 @default.
- W3186379961 cites W2790416725 @default.
- W3186379961 cites W2791176877 @default.
- W3186379961 cites W2792269502 @default.
- W3186379961 cites W2803159538 @default.
- W3186379961 cites W2805924527 @default.
- W3186379961 cites W2890105461 @default.
- W3186379961 cites W2923928973 @default.
- W3186379961 cites W2945540780 @default.
- W3186379961 cites W2948903363 @default.
- W3186379961 cites W2974514979 @default.
- W3186379961 cites W2981614323 @default.
- W3186379961 cites W2999702475 @default.
- W3186379961 cites W3005464218 @default.
- W3186379961 cites W3080735488 @default.
- W3186379961 cites W3087839964 @default.
- W3186379961 cites W3096205984 @default.
- W3186379961 doi "https://doi.org/10.1101/2021.07.15.452523" @default.
- W3186379961 hasPublicationYear "2021" @default.
- W3186379961 type Work @default.
- W3186379961 sameAs 3186379961 @default.
- W3186379961 citedByCount "1" @default.
- W3186379961 countsByYear W31863799612021 @default.
- W3186379961 crossrefType "posted-content" @default.
- W3186379961 hasAuthorship W3186379961A5003793915 @default.
- W3186379961 hasAuthorship W3186379961A5005519536 @default.
- W3186379961 hasAuthorship W3186379961A5005786535 @default.
- W3186379961 hasAuthorship W3186379961A5014752134 @default.
- W3186379961 hasAuthorship W3186379961A5022113009 @default.
- W3186379961 hasAuthorship W3186379961A5027643261 @default.
- W3186379961 hasAuthorship W3186379961A5037288031 @default.
- W3186379961 hasAuthorship W3186379961A5038646281 @default.
- W3186379961 hasAuthorship W3186379961A5046010698 @default.
- W3186379961 hasAuthorship W3186379961A5055095007 @default.