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• W3186383890 endingPage "131195" @default.
• W3186383890 startingPage "131195" @default.
• W3186383890 abstract "• Nanofibrous scaffolds with excellent biodegradability and biocompatibility remains an important challenge in the healing of damaged tissues. • Al 2 O 3 nanoparticles modifieded PVP scaffold was prepared by using an electrospinning technique. • The Al 2 O 3 /PVP nanofibrous scaffold scavenging the reactive oxygen species and facilitate cell proliferation which led to rapid re-epithelialization. • Thus, our designed nanofibrous scaffold is suitable for promoting burn wound repair. Recently, ceramics have been enormously using for drug delivery applications. Alumina (Al 2 O 3 ) is a common ceramic material, offering enhanced reliability and excellent performance in wound healing applications. Thus, this work aimed to fabricate an Al 2 O 3 based polyvinylpyrrolidone (PVP) nanofibrous scaffolds. The prepared nanofibrous scaffolds were characterized for morphology and chemical structure by a collection of joint techniques, including SEM, TEM, AFM, FTIR, UV-vis-NIR and DSC. Furthermore, porosity, degradation and drug-releasing ability of the nanofibrous scaffolds were investigated. The antimicrobial activity of the nanofibrous scaffolds was tested against two bacterial strains (S. aureus and E. coli) by the agar diffusion method. Also, the biocompatibility test of the obtained nanofibrous scaffolds was evaluated using fibroblast cells (L929). Based on in vivo burn wound healing model Al 2 O 3 /PVP nanofibrous scaffold significantly hastening the wound healing process by facilitating re-epithelialization as well as collagen synthesis. The present study concludes that the Al 2 O 3 modified PVP nanofibrous scaffold has great potential in wound healing for the treatment of burn wounds." @default.
• W3186383890 created "2021-08-02" @default.
• W3186383890 creator A5001931238 @default.
• W3186383890 creator A5005564854 @default.
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• W3186383890 date "2021-12-01" @default.
• W3186383890 modified "2023-09-29" @default.
• W3186383890 title "Biologically important alumina nanoparticles modified polyvinylpyrrolidone scaffolds in vitro characterizations and it is in vivo wound healing efficacy" @default.
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• W3186383890 doi "https://doi.org/10.1016/j.molstruc.2021.131195" @default.
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