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- W3186389620 abstract "Cancer is one of the leading causes of death worldwide and remains a major public health challenge. The introduction of more sensitive and powerful technologies has permitted the appearance of new tumor-specific molecular aberrations with a significant cancer management improvement. Therefore, molecular pathology profiling has become fundamental not only to guide tumor diagnosis and prognosis but also to assist with therapeutic decisions in daily practice. Although tumor biopsies continue to be mandatory in cancer diagnosis and classification, several studies have demonstrated that liquid biopsies could be used as a potential tool for the detection of cancer-specific biomarkers. One of the main advantages is that circulating free DNA (cfDNA) provides information about intra-tumoral heterogeneity, reflecting dynamic changes in tumor burden. This minimally invasive tool has become an accurate and reliable instrument for monitoring cancer genetics. However, implementing liquid biopsies across the clinical practice is still ongoing. The main challenge is to detect genomic alterations at low allele fractions. Droplet digital PCR (ddPCR) is a powerful approach that can overcome this issue due to its high sensitivity and specificity. Here we explore the real-world clinical utility of the liquid biopsy ddPCR assays in the most diagnosed cancer subtypes." @default.
- W3186389620 created "2021-08-02" @default.
- W3186389620 creator A5019296073 @default.
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- W3186389620 creator A5052770381 @default.
- W3186389620 creator A5056610775 @default.
- W3186389620 creator A5079254239 @default.
- W3186389620 creator A5086535166 @default.
- W3186389620 date "2021-07-28" @default.
- W3186389620 modified "2023-10-18" @default.
- W3186389620 title "Clinical Utility of Liquid Biopsy-Based Actionable Mutations Detected via ddPCR" @default.
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