Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186392207> ?p ?o ?g. }
- W3186392207 abstract "ABSTRACT Importance Pediatric concussion has a rising incidence and can lead to long-term symptoms in nearly 30% of children. Resting state functional magnetic resonance imaging (rs-fMRI) disturbances are a common pathological feature of concussion, though no studies have examined sex-differences with respect to this outcome. Despite known sex-differences in how pediatric concussion presents, females have remained understudied in rs-fMRI studies, precluding a sex-specific understanding of the functional neuropathology of pediatric concussion. Objective To provide the first insights into sex-specific rs-fMRI differences in pediatric concussion. Design, setting, and participants Secondary data analysis of rs-fMRI data collected on children with concussion recruited from in a pediatric hospital setting, with control data accessed from the open-source ABIDE-II database. In total, 27 children with concussion (14 females) approximately one-month post-injury and 1:1 age- and sex-matched healthy controls comprised our sample. Exposure Patients received a physician diagnosis of concussion. ABIDE-II healthy controls were typically developing. Main outcomes & measures Seed-based (which permitted an examination of whole-brain connectivity, fitting with the exploratory nature of the present study) and region of interest (ROI) analyses were used to examine sex-based rs-fMRI differences. Threshold-free cluster enhancement (TFCE) and a family-wise error (FWE) corrected p-values were used to identify significantly different clusters. Results In comparing females with concussion to healthy females, seed-based analyses (in order of largest effect) showed hypo-connectivity between the anterior cingulate cortex of the salience network and the precuneus (TFCE=1173.6, p=FWE=0.002) and cingulate gyrus (TFCE=1039.7, p-FWE=0.008), and the posterior cingulate cortex (PCC) of the default mode network and the paracingulate gyrus (TFCE=870.1, p-FWE=0.015) and sub-callosal cortex (TFCE=795.4, p-FWE=0.037); hyper-connectivity was observed between the lateral pre-frontal cortex and inferior frontal gyrus (TFCE=1215.4, p-FWE=0.002) and lateral occipital cortex (TFCE=854.9, p-FWE=0.020) and between the PCC and cerebellum (TFCE=791.0, p-FWE=0.038). ROI analyses showed primarily patterns of hyper-connectivity in females. No differences were observed between males with concussion and healthy males on seed-based or ROI analyses. Conclusions and relevance There are alterations in rs-fMRI in females with concussion at one-month post-injury that are not present in males, which provides further evidence that recovery timelines in pediatric concussion may differ by sex. KEY FINDINGS Question Are there sex-differences in resting state functional brain activity in pediatric concussion? Findings Females with concussion show both hyper- and hypo-connectivity between multiple brain regions when compared to healthy age- and sex-matched controls. The same analyses revealed no differences in resting state brain activity when comparing males with concussion to their age- and sex-matched healthy peers. Meaning There are sex-differences in resting state brain activity in pediatric concussion. This suggests that the functional neuropathology of the injury differs between males and females, which may account for sex-differences in the clinical presentation of pediatric concussion." @default.
- W3186392207 created "2021-08-02" @default.
- W3186392207 creator A5015849619 @default.
- W3186392207 creator A5020236936 @default.
- W3186392207 creator A5062918564 @default.
- W3186392207 creator A5074228294 @default.
- W3186392207 date "2021-07-18" @default.
- W3186392207 modified "2023-09-27" @default.
- W3186392207 title "Sex-specific differences in resting-state functional brain activity in pediatric concussion" @default.
- W3186392207 cites W1971356024 @default.
- W3186392207 cites W1973776237 @default.
- W3186392207 cites W1983183519 @default.
- W3186392207 cites W1991120403 @default.
- W3186392207 cites W1997819451 @default.
- W3186392207 cites W2000567681 @default.
- W3186392207 cites W2005238835 @default.
- W3186392207 cites W2009792683 @default.
- W3186392207 cites W2017414981 @default.
- W3186392207 cites W2042739149 @default.
- W3186392207 cites W2046557060 @default.
- W3186392207 cites W2052337396 @default.
- W3186392207 cites W2069088601 @default.
- W3186392207 cites W2072815937 @default.
- W3186392207 cites W2095491050 @default.
- W3186392207 cites W2130010412 @default.
- W3186392207 cites W2150696106 @default.
- W3186392207 cites W2283197677 @default.
- W3186392207 cites W2294499182 @default.
- W3186392207 cites W2296634983 @default.
- W3186392207 cites W2482417927 @default.
- W3186392207 cites W2505372533 @default.
- W3186392207 cites W2560693837 @default.
- W3186392207 cites W2571255524 @default.
- W3186392207 cites W2577370916 @default.
- W3186392207 cites W2592148734 @default.
- W3186392207 cites W2601707947 @default.
- W3186392207 cites W2607525868 @default.
- W3186392207 cites W2608296280 @default.
- W3186392207 cites W2610287704 @default.
- W3186392207 cites W2760961058 @default.
- W3186392207 cites W2766786132 @default.
- W3186392207 cites W2770111046 @default.
- W3186392207 cites W2797548083 @default.
- W3186392207 cites W2806551037 @default.
- W3186392207 cites W2888206153 @default.
- W3186392207 cites W2900109014 @default.
- W3186392207 cites W2900497911 @default.
- W3186392207 cites W2905212241 @default.
- W3186392207 cites W2909228725 @default.
- W3186392207 cites W2949554381 @default.
- W3186392207 cites W2956753577 @default.
- W3186392207 cites W2966111652 @default.
- W3186392207 cites W2968068770 @default.
- W3186392207 cites W2990608051 @default.
- W3186392207 cites W2996942902 @default.
- W3186392207 cites W3003889104 @default.
- W3186392207 cites W3006197455 @default.
- W3186392207 cites W3033217546 @default.
- W3186392207 cites W3035738231 @default.
- W3186392207 cites W3037703429 @default.
- W3186392207 cites W3093429210 @default.
- W3186392207 cites W3134036388 @default.
- W3186392207 cites W3140720727 @default.
- W3186392207 cites W4254073079 @default.
- W3186392207 cites W4376848396 @default.
- W3186392207 doi "https://doi.org/10.1101/2021.07.14.21260531" @default.
- W3186392207 hasPublicationYear "2021" @default.
- W3186392207 type Work @default.
- W3186392207 sameAs 3186392207 @default.
- W3186392207 citedByCount "0" @default.
- W3186392207 crossrefType "posted-content" @default.
- W3186392207 hasAuthorship W3186392207A5015849619 @default.
- W3186392207 hasAuthorship W3186392207A5020236936 @default.
- W3186392207 hasAuthorship W3186392207A5062918564 @default.
- W3186392207 hasAuthorship W3186392207A5074228294 @default.
- W3186392207 hasBestOaLocation W31863922071 @default.
- W3186392207 hasConcept C118552586 @default.
- W3186392207 hasConcept C15744967 @default.
- W3186392207 hasConcept C169760540 @default.
- W3186392207 hasConcept C169900460 @default.
- W3186392207 hasConcept C190385971 @default.
- W3186392207 hasConcept C2778402161 @default.
- W3186392207 hasConcept C2778426673 @default.
- W3186392207 hasConcept C2779226451 @default.
- W3186392207 hasConcept C3017944768 @default.
- W3186392207 hasConcept C548259974 @default.
- W3186392207 hasConcept C71924100 @default.
- W3186392207 hasConcept C99454951 @default.
- W3186392207 hasConcept C99508421 @default.
- W3186392207 hasConceptScore W3186392207C118552586 @default.
- W3186392207 hasConceptScore W3186392207C15744967 @default.
- W3186392207 hasConceptScore W3186392207C169760540 @default.
- W3186392207 hasConceptScore W3186392207C169900460 @default.
- W3186392207 hasConceptScore W3186392207C190385971 @default.
- W3186392207 hasConceptScore W3186392207C2778402161 @default.
- W3186392207 hasConceptScore W3186392207C2778426673 @default.
- W3186392207 hasConceptScore W3186392207C2779226451 @default.
- W3186392207 hasConceptScore W3186392207C3017944768 @default.
- W3186392207 hasConceptScore W3186392207C548259974 @default.
- W3186392207 hasConceptScore W3186392207C71924100 @default.