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• W3186393162 abstract "T cells play an important role in the adaptive immune response to a variety of infections and cancers. Initiation of a T cell mediated immune response requires antigen recognition in a process termed MHC (major histocompatibility complex) restri ction. A T cell antigen is a composite structure made up of a peptide fragment bound within the antigen-binding groove of an MHC-encoded class I or class II molecule. Insight into the precise composition and biology of self and non-self immunopeptidomes is essential to harness T cell mediated immunity to prevent, treat, or cure infectious diseases and cancers. T cell antigen discovery is an arduous task! The pioneering work in the early 1990s has made large-scale T cell antigen discovery possible. Thus, advancements in mass spectrometry coupled with proteomics and genomics technologies make possible T cell antigen discovery with ease, accuracy, and sensitivity. Yet we have only begun to understand the breadth and the depth of self and non-self immunopeptidomes because the molecular biology of the cell continues to surprise us with new secrets directly related to the source, and the processing and presentation of MHC ligands. Focused on MHC class I molecules, this review, therefore, provides a brief historic account of T cell antigen discovery and, against a backdrop of key advances in molecular cell biologic processes, elaborates on how proteogenomics approaches have revolutionised the field." @default.
• W3186393162 created "2021-08-02" @default.
• W3186393162 creator A5035984241 @default.
• W3186393162 creator A5090536136 @default.
• W3186393162 date "2021-08-09" @default.
• W3186393162 modified "2023-10-18" @default.
• W3186393162 title "Know thy immune self and non‐self: Proteomics informs on the expanse of self and non‐self, and how and where they arise" @default.
• W3186393162 cites W1456162119 @default.
• W3186393162 cites W1487735178 @default.
• W3186393162 cites W1501288691 @default.
• W3186393162 cites W1512441015 @default.
• W3186393162 cites W1518612434 @default.
• W3186393162 cites W1521491171 @default.
• W3186393162 cites W1541199151 @default.
• W3186393162 cites W1547700243 @default.
• W3186393162 cites W1553822907 @default.
• W3186393162 cites W1570231448 @default.
• W3186393162 cites W1574920081 @default.
• W3186393162 cites W1589281113 @default.
• W3186393162 cites W1608008200 @default.
• W3186393162 cites W1696310851 @default.
• W3186393162 cites W174468170 @default.
• W3186393162 cites W1782287000 @default.
• W3186393162 cites W1809576401 @default.
• W3186393162 cites W1826123378 @default.
• W3186393162 cites W1913018482 @default.
• W3186393162 cites W1917255134 @default.
• W3186393162 cites W1933245690 @default.
• W3186393162 cites W1933948779 @default.
• W3186393162 cites W1960514362 @default.
• W3186393162 cites W1963655619 @default.
• W3186393162 cites W1967483303 @default.
• W3186393162 cites W1967582433 @default.
• W3186393162 cites W1969039415 @default.
• W3186393162 cites W1970089737 @default.
• W3186393162 cites W1971302107 @default.
• W3186393162 cites W1972103487 @default.
• W3186393162 cites W1972899685 @default.
• W3186393162 cites W1972966267 @default.
• W3186393162 cites W1973635674 @default.
• W3186393162 cites W1974746017 @default.
• W3186393162 cites W1976251709 @default.
• W3186393162 cites W1976294252 @default.
• W3186393162 cites W1976296968 @default.
• W3186393162 cites W1976482695 @default.
• W3186393162 cites W1977409285 @default.
• W3186393162 cites W1978480556 @default.
• W3186393162 cites W1979731533 @default.
• W3186393162 cites W1981106544 @default.
• W3186393162 cites W1981338942 @default.
• W3186393162 cites W1984393944 @default.
• W3186393162 cites W1985495705 @default.
• W3186393162 cites W1985774274 @default.
• W3186393162 cites W1987668067 @default.
• W3186393162 cites W1994947913 @default.
• W3186393162 cites W1995317534 @default.
• W3186393162 cites W1995448798 @default.
• W3186393162 cites W1998240361 @default.
• W3186393162 cites W1998548282 @default.
• W3186393162 cites W2000251753 @default.
• W3186393162 cites W2000779612 @default.
• W3186393162 cites W2001788095 @default.
• W3186393162 cites W2004764054 @default.
• W3186393162 cites W2006629564 @default.
• W3186393162 cites W2006759360 @default.
• W3186393162 cites W2007026865 @default.
• W3186393162 cites W2009115410 @default.
• W3186393162 cites W2009541708 @default.
• W3186393162 cites W2010475189 @default.
• W3186393162 cites W2011458181 @default.
• W3186393162 cites W2011833868 @default.
• W3186393162 cites W2012324563 @default.
• W3186393162 cites W2014750653 @default.
• W3186393162 cites W2014946585 @default.
• W3186393162 cites W2015257762 @default.
• W3186393162 cites W2017082201 @default.
• W3186393162 cites W2018327543 @default.
• W3186393162 cites W2019262012 @default.
• W3186393162 cites W2019711015 @default.
• W3186393162 cites W2019993505 @default.
• W3186393162 cites W2020923013 @default.
• W3186393162 cites W2021673674 @default.
• W3186393162 cites W2022861083 @default.
• W3186393162 cites W2025031883 @default.
• W3186393162 cites W2025071373 @default.
• W3186393162 cites W2026506656 @default.
• W3186393162 cites W2029459862 @default.
• W3186393162 cites W2029993034 @default.
• W3186393162 cites W2031280710 @default.
• W3186393162 cites W2031656934 @default.
• W3186393162 cites W2031951044 @default.
• W3186393162 cites W2032592226 @default.
• W3186393162 cites W2033605807 @default.
• W3186393162 cites W2034298592 @default.
• W3186393162 cites W2034764834 @default.
• W3186393162 cites W2039848934 @default.
• W3186393162 cites W2040798864 @default.
• W3186393162 cites W2041034033 @default.
• W3186393162 cites W2041261341 @default.
• W3186393162 cites W2041426680 @default.

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