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- W3186394908 endingPage "1608" @default.
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- W3186394908 abstract "Background: While early life exposures such as mode of birth, breastfeeding, and antibiotic use are established regulators of microbiome composition in early childhood, recent research suggests that the social environment may also exert influence. Two recent studies in adults demonstrated associations between socioeconomic factors and microbiome composition. This study expands on this prior work by examining the association between family socioeconomic status (SES) and host genetics with microbiome composition in infants and children. Methods: Family SES was used to predict a latent variable representing six genera abundances generated from whole-genome shotgun sequencing. A polygenic score derived from a microbiome genome-wide association study was included to control for potential genetic associations. Associations between family SES and microbiome diversity were assessed. Results: Anaerostipes, Bacteroides, Eubacterium, Faecalibacterium, and Lachnospiraceae spp. significantly loaded onto a latent factor, which was significantly predicted by SES (p < 0.05) but not the polygenic score (p > 0.05). Our results indicate that SES did not predict alpha diversity but did predict beta diversity (p < 0.001). Conclusions: Our results demonstrate that modifiable environmental factors influence gut microbiome composition at an early age. These results are important as our understanding of gut microbiome influences on health continue to expand." @default.
- W3186394908 created "2021-08-02" @default.
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- W3186394908 date "2021-07-28" @default.
- W3186394908 modified "2023-10-13" @default.
- W3186394908 title "Family SES Is Associated with the Gut Microbiome in Infants and Children" @default.
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- W3186394908 doi "https://doi.org/10.3390/microorganisms9081608" @default.
- W3186394908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8398307" @default.
- W3186394908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34442687" @default.
- W3186394908 hasPublicationYear "2021" @default.