FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186402816> ?p ?o ?g. }

• W3186402816 endingPage "1488" @default.
• W3186402816 startingPage "1488" @default.
• W3186402816 abstract "Insulin-like growth factor-1 (IGF-1) and the IGF-1 receptor (IGF-1R) belong to the insulin-like growth factor family, and IGF-1 activates intracellular signaling pathways by binding specifically to IGF-1R. The interaction between IGF-1 and IGF-1R transmits a signal through a number of intracellular substrates, including the insulin receptor substrate (IRS) and the Src homology collagen (Shc) proteins, which activate two major intracellular signaling pathways: the phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen-activated protein kinase (MAPK) pathways, specifically the extracellular signal-regulated kinase (ERK) pathways. The PI3K/AKT kinase pathway regulates a variety of cellular processes, including cell proliferation and apoptosis. IGF1/IGF-1R signaling also promotes cell differentiation and proliferation via the Ras/MAPK pathway. Moreover, upon IGF-1R activation of the IRS and Shc adaptor proteins, Shc stimulates Raf through the GTPase Ras to activate the MAPKs ERK1 and ERK2, phosphorylate and several other proteins, and to stimulate cell proliferation. The IGF-1 signaling pathway is required for certain viral effects in oncogenic progression and may be induced as an effect of viral infection. The mechanisms of IGF signaling in animal viral infections need to be clarified, mainly because they are involved in multifactorial signaling pathways. The aim of this review is to summarize the current data obtained from virological studies and to increase our understanding of the complex role of the IGF-1 signaling axis in animal virus infections." @default.
• W3186402816 created "2021-08-02" @default.
• W3186402816 creator A5005021789 @default.
• W3186402816 creator A5033330550 @default.
• W3186402816 creator A5033931336 @default.
• W3186402816 creator A5064263048 @default.
• W3186402816 date "2021-07-29" @default.
• W3186402816 modified "2023-10-14" @default.
• W3186402816 title "The IGF-1 Signaling Pathway in Viral Infections" @default.
• W3186402816 cites W1577885672 @default.
• W3186402816 cites W1580326294 @default.
• W3186402816 cites W1789124686 @default.
• W3186402816 cites W1930900885 @default.
• W3186402816 cites W1968898334 @default.
• W3186402816 cites W1969916031 @default.
• W3186402816 cites W1975736029 @default.
• W3186402816 cites W1977306646 @default.
• W3186402816 cites W1985132587 @default.
• W3186402816 cites W1995422830 @default.
• W3186402816 cites W2003340108 @default.
• W3186402816 cites W2005505016 @default.
• W3186402816 cites W2007251242 @default.
• W3186402816 cites W2015952795 @default.
• W3186402816 cites W2017536128 @default.
• W3186402816 cites W2020576231 @default.
• W3186402816 cites W2023460369 @default.
• W3186402816 cites W2023965168 @default.
• W3186402816 cites W2025299909 @default.
• W3186402816 cites W2027454234 @default.
• W3186402816 cites W2044099516 @default.
• W3186402816 cites W2049885911 @default.
• W3186402816 cites W2050745359 @default.
• W3186402816 cites W2051712052 @default.
• W3186402816 cites W2051883154 @default.
• W3186402816 cites W2058814481 @default.
• W3186402816 cites W2062292251 @default.
• W3186402816 cites W2067275727 @default.
• W3186402816 cites W2082916697 @default.
• W3186402816 cites W2088254663 @default.
• W3186402816 cites W2089577924 @default.
• W3186402816 cites W2091581218 @default.
• W3186402816 cites W2096081010 @default.
• W3186402816 cites W2098204011 @default.
• W3186402816 cites W2102649531 @default.
• W3186402816 cites W2109125050 @default.
• W3186402816 cites W2109465993 @default.
• W3186402816 cites W2118251904 @default.
• W3186402816 cites W2138355348 @default.
• W3186402816 cites W2139807161 @default.
• W3186402816 cites W2141110021 @default.
• W3186402816 cites W2145873481 @default.
• W3186402816 cites W2147114673 @default.
• W3186402816 cites W2150658610 @default.
• W3186402816 cites W2312401900 @default.
• W3186402816 cites W2517957586 @default.
• W3186402816 cites W2521682440 @default.
• W3186402816 cites W2523360988 @default.
• W3186402816 cites W2528581834 @default.
• W3186402816 cites W2567402395 @default.
• W3186402816 cites W2635415917 @default.
• W3186402816 cites W2735480792 @default.
• W3186402816 cites W2751739209 @default.
• W3186402816 cites W2754999143 @default.
• W3186402816 cites W2755211939 @default.
• W3186402816 cites W2758568440 @default.
• W3186402816 cites W2778876312 @default.
• W3186402816 cites W2784223323 @default.
• W3186402816 cites W2789444527 @default.
• W3186402816 cites W2803476523 @default.
• W3186402816 cites W2972397941 @default.
• W3186402816 cites W3032889003 @default.
• W3186402816 cites W3048234386 @default.
• W3186402816 cites W3082237465 @default.
• W3186402816 cites W3088838661 @default.
• W3186402816 cites W3122657532 @default.
• W3186402816 doi "https://doi.org/10.3390/v13081488" @default.
• W3186402816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8402757" @default.
• W3186402816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34452353" @default.
• W3186402816 hasPublicationYear "2021" @default.
• W3186402816 type Work @default.
• W3186402816 sameAs 3186402816 @default.
• W3186402816 citedByCount "25" @default.
• W3186402816 countsByYear W31864028162021 @default.
• W3186402816 countsByYear W31864028162022 @default.
• W3186402816 countsByYear W31864028162023 @default.
• W3186402816 crossrefType "journal-article" @default.
• W3186402816 hasAuthorship W3186402816A5005021789 @default.
• W3186402816 hasAuthorship W3186402816A5033330550 @default.
• W3186402816 hasAuthorship W3186402816A5033931336 @default.
• W3186402816 hasAuthorship W3186402816A5064263048 @default.
• W3186402816 hasBestOaLocation W31864028161 @default.
• W3186402816 hasConcept C170493617 @default.
• W3186402816 hasConcept C183786373 @default.
• W3186402816 hasConcept C184235292 @default.
• W3186402816 hasConcept C2775960820 @default.
• W3186402816 hasConcept C2780689927 @default.
• W3186402816 hasConcept C2909831755 @default.
• W3186402816 hasConcept C55493867 @default.

• next