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• W3186451251 endingPage "113468" @default.
• W3186451251 startingPage "113468" @default.
• W3186451251 abstract "Parvalbumin (PV)-expressing neurons have been implicated in the pathology of autism spectrum disorders (ASD). Loss of PV expression and/or reduced number of PV-expressing neurons have been reported not only in genetic and environmental rodent models of ASD, but also in post-mortem analyses of brain tissues from ASD vs. healthy control human subjects. PV-expressing neurons play a pivotal role in the maintenance of the balance between excitation and inhibition within neural circuits in part because of their fast-spiking properties. Their high firing rate is mostly regulated by the voltage-gated potassium channel Kv3.1. It is yet unknown whether disturbances in the electrophysiological properties of PV-expressing neurons per se can lead to behavioral disturbances. We assessed locomotor activity, social interaction, recognition and memory, and stereotypic behaviors in Kv3.1 wild-type (WT) and knockout (KO) mice. We then used Western Blot analyses to measure the impact of Kv3.1 deficiency on markers of GABA transmission (PV and GAD67) and neural circuit activity (Egr1). Deficiency in Kv3.1 channel is sufficient to induce social deficits, hyperactivity and stereotypic behaviors. These behavioral changes were independent of changes in GAD67 levels and associated with increased levels of PV protein in the prefrontal cortex and striatum. These findings reveal that a loss of PV expression is not a necessary factor to induce an ASD-like phenotype in mice and support the need for further investigation to fully understand the contribution of PV-expressing neurons to ASD pathology." @default.
• W3186451251 created "2021-08-02" @default.
• W3186451251 creator A5044232164 @default.
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• W3186451251 date "2021-09-01" @default.
• W3186451251 modified "2023-09-23" @default.
• W3186451251 title "Social impairments in mice lacking the voltage-gated potassium channel Kv3.1" @default.
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• W3186451251 doi "https://doi.org/10.1016/j.bbr.2021.113468" @default.
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• W3186451251 hasPublicationYear "2021" @default.
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