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- W3186503393 abstract "Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine carcinoma. It initially responds to chemotherapy but rapidly becomes chemoresistant and it is highly proliferative. The prognosis in SCLC is poor . We have established a novel SCLC cell line, SCLC-J1, from a malignant pleural effusion in a patient with advanced SCLC . SCLC-J1 cells express ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost. These features of the new SCLC cell line may be useful in understanding the cellular and molecular biology of SCLC and in designing better treatment. • A novel small lung cancer cell line, SCLC-J1, was successfully established. • SCLC-J1 cells express the tumor-specific antigens ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost. • SCLC-J1 will provide insights into SCLC biology that may permit better therapeutic targeting." @default.
- W3186503393 created "2021-08-02" @default.
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- W3186503393 date "2021-09-01" @default.
- W3186503393 modified "2023-10-15" @default.
- W3186503393 title "SCLC-J1, a novel small cell lung cancer cell line" @default.
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- W3186503393 doi "https://doi.org/10.1016/j.bbrep.2021.101089" @default.
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