Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186552610> ?p ?o ?g. }
- W3186552610 endingPage "7982" @default.
- W3186552610 startingPage "7982" @default.
- W3186552610 abstract "Adaptation of organisms to stressors is coordinated by the hypothalamic-pituitary-adrenal axis (HPA), which involves glucocorticoids (GCs) and glucocorticoid receptors (GRs). Although the effects of GCs are well characterized, their impact on brain adaptation to hypoxia/ischemia is still understudied. The brain is not only the most susceptible to hypoxic injury, but also vulnerable to GC-induced damage, which makes studying the mechanisms of brain hypoxic tolerance and resistance to stress-related elevation of GCs of great importance. Cross-talk between the molecular mechanisms activated in neuronal cells by hypoxia and GCs provides a platform for developing the most effective and safe means for prevention and treatment of hypoxia-induced brain damage, including hypoxic pre- and post-conditioning. Taking into account that hypoxia- and GC-induced reprogramming significantly affects the development of organisms during embryogenesis, studies of the effects of prenatal and neonatal hypoxia on health in later life are of particular interest. This mini review discusses the accumulated data on the dynamics of the HPA activation in injurious and non-injurious hypoxia, the role of the brain GRs in these processes, interaction of GCs and hypoxia-inducible factor HIF-1, as well as cross-talk between GC and hypoxic signaling. It also identifies underdeveloped areas and suggests directions for further prospective studies." @default.
- W3186552610 created "2021-08-02" @default.
- W3186552610 creator A5082657076 @default.
- W3186552610 creator A5083214689 @default.
- W3186552610 date "2021-07-26" @default.
- W3186552610 modified "2023-10-01" @default.
- W3186552610 title "Glucocorticoid-Dependent Mechanisms of Brain Tolerance to Hypoxia" @default.
- W3186552610 cites W1010562381 @default.
- W3186552610 cites W1593018684 @default.
- W3186552610 cites W1905851972 @default.
- W3186552610 cites W1966991190 @default.
- W3186552610 cites W1968806822 @default.
- W3186552610 cites W1980576189 @default.
- W3186552610 cites W1988480519 @default.
- W3186552610 cites W1989736478 @default.
- W3186552610 cites W1991674115 @default.
- W3186552610 cites W1992568202 @default.
- W3186552610 cites W1994062771 @default.
- W3186552610 cites W1994185060 @default.
- W3186552610 cites W1994609038 @default.
- W3186552610 cites W1995474262 @default.
- W3186552610 cites W1999201062 @default.
- W3186552610 cites W2012341457 @default.
- W3186552610 cites W2017964197 @default.
- W3186552610 cites W2020761608 @default.
- W3186552610 cites W2021846928 @default.
- W3186552610 cites W2030080879 @default.
- W3186552610 cites W2032226181 @default.
- W3186552610 cites W2033499475 @default.
- W3186552610 cites W2033958147 @default.
- W3186552610 cites W2036845348 @default.
- W3186552610 cites W2038541687 @default.
- W3186552610 cites W2039384122 @default.
- W3186552610 cites W2047012655 @default.
- W3186552610 cites W2048448310 @default.
- W3186552610 cites W2050026048 @default.
- W3186552610 cites W2060254175 @default.
- W3186552610 cites W2064178384 @default.
- W3186552610 cites W2067181732 @default.
- W3186552610 cites W2069109537 @default.
- W3186552610 cites W2071361463 @default.
- W3186552610 cites W2072963303 @default.
- W3186552610 cites W2074802748 @default.
- W3186552610 cites W2078675270 @default.
- W3186552610 cites W2079067885 @default.
- W3186552610 cites W2079533675 @default.
- W3186552610 cites W2083103946 @default.
- W3186552610 cites W2084977349 @default.
- W3186552610 cites W2091784429 @default.
- W3186552610 cites W2094859050 @default.
- W3186552610 cites W2096820421 @default.
- W3186552610 cites W2098972920 @default.
- W3186552610 cites W2107389791 @default.
- W3186552610 cites W2113679122 @default.
- W3186552610 cites W2125045089 @default.
- W3186552610 cites W2126370598 @default.
- W3186552610 cites W2128261857 @default.
- W3186552610 cites W2139466694 @default.
- W3186552610 cites W2142482515 @default.
- W3186552610 cites W2144101679 @default.
- W3186552610 cites W2166018343 @default.
- W3186552610 cites W2172063972 @default.
- W3186552610 cites W2177511714 @default.
- W3186552610 cites W2179556324 @default.
- W3186552610 cites W2227840549 @default.
- W3186552610 cites W2237311983 @default.
- W3186552610 cites W2272525849 @default.
- W3186552610 cites W2287499807 @default.
- W3186552610 cites W2295904380 @default.
- W3186552610 cites W2344078301 @default.
- W3186552610 cites W2428681212 @default.
- W3186552610 cites W2517981825 @default.
- W3186552610 cites W2578678089 @default.
- W3186552610 cites W2593054923 @default.
- W3186552610 cites W2607000416 @default.
- W3186552610 cites W2613922084 @default.
- W3186552610 cites W2753524273 @default.
- W3186552610 cites W2768531116 @default.
- W3186552610 cites W2790144497 @default.
- W3186552610 cites W2792344067 @default.
- W3186552610 cites W2795436883 @default.
- W3186552610 cites W2808836151 @default.
- W3186552610 cites W2810336466 @default.
- W3186552610 cites W2900795135 @default.
- W3186552610 cites W2901879461 @default.
- W3186552610 cites W2904389548 @default.
- W3186552610 cites W2932013542 @default.
- W3186552610 cites W2940578551 @default.
- W3186552610 cites W2958126327 @default.
- W3186552610 cites W2979742504 @default.
- W3186552610 cites W2995854345 @default.
- W3186552610 cites W2997382815 @default.
- W3186552610 cites W3002515666 @default.
- W3186552610 cites W3020830575 @default.
- W3186552610 cites W3027345678 @default.
- W3186552610 cites W3049263567 @default.
- W3186552610 cites W3112448382 @default.
- W3186552610 cites W3116842426 @default.