FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186553742> ?p ?o ?g. }

• W3186553742 endingPage "20" @default.
• W3186553742 startingPage "11" @default.
• W3186553742 abstract "<b><i>Background:</i></b> Accumulating evidence has suggested that the bi-directional communication pathway, the microbiota-gut-brain axis, plays an important role in the pathophysiology of many neuropsychiatric diseases including major depressive disorder (MDD). This review outlines current evidence and promising findings related to the pathophysiology and treatment of MDD. <b><i>Summary:</i></b> There are at least 4 key biological molecules/systems underlying the pathophysiology of MDD: central dopamine, stress responses by the hypothalamic-pituitary-adrenal axis and autonomic nervous system, inflammation, and brain-derived neurotrophic factor. Animal experiments in several depression models have clearly indicated that gut microbiota is closely related to these molecules/systems and administration of probiotics and prebitotics may have beneficial effects on them. Although the results of microbiota profile of MDD patients varied from a study to another, multiple studies reported that bacteria which produce short-chain fatty acids such as butyrate and those protective against metabolic diseases (e.g., Bacteroidetes) were reduced. Clinical trials of probiotics have emerged, and the majority of the studies have reported beneficial effects on depression symptoms and related biological markers. <b><i>Key Messages:</i></b> The accumulating evidence suggests that research on the microbiota-gut-brain axis in major depressive disorder (MDD) is promising to elucidate the pathophysiology and to develop novel treatment of MDD, although there is still a long distance yet to reach the goals." @default.
• W3186553742 created "2021-08-02" @default.
• W3186553742 creator A5021063513 @default.
• W3186553742 date "2021-01-01" @default.
• W3186553742 modified "2023-10-13" @default.
• W3186553742 title "Gut Microbiota and Pathophysiology of Depressive Disorder" @default.
• W3186553742 cites W1529178472 @default.
• W3186553742 cites W1578958407 @default.
• W3186553742 cites W1706907302 @default.
• W3186553742 cites W1768927256 @default.
• W3186553742 cites W1898759202 @default.
• W3186553742 cites W1966452112 @default.
• W3186553742 cites W1970174017 @default.
• W3186553742 cites W1974182801 @default.
• W3186553742 cites W1977804070 @default.
• W3186553742 cites W1978830885 @default.
• W3186553742 cites W1984285653 @default.
• W3186553742 cites W1984567634 @default.
• W3186553742 cites W1987433942 @default.
• W3186553742 cites W1990912500 @default.
• W3186553742 cites W1996454121 @default.
• W3186553742 cites W2002714430 @default.
• W3186553742 cites W2003070777 @default.
• W3186553742 cites W2004506978 @default.
• W3186553742 cites W2014377614 @default.
• W3186553742 cites W2016843603 @default.
• W3186553742 cites W2017902083 @default.
• W3186553742 cites W2031441917 @default.
• W3186553742 cites W2055747883 @default.
• W3186553742 cites W2059491535 @default.
• W3186553742 cites W2063393311 @default.
• W3186553742 cites W2064210408 @default.
• W3186553742 cites W2068731812 @default.
• W3186553742 cites W2070993776 @default.
• W3186553742 cites W2073269192 @default.
• W3186553742 cites W2073332363 @default.
• W3186553742 cites W2075618111 @default.
• W3186553742 cites W2084255439 @default.
• W3186553742 cites W2084736890 @default.
• W3186553742 cites W2084880238 @default.
• W3186553742 cites W2087418736 @default.
• W3186553742 cites W2089198034 @default.
• W3186553742 cites W2108580074 @default.
• W3186553742 cites W2109113634 @default.
• W3186553742 cites W2113822705 @default.
• W3186553742 cites W2126531992 @default.
• W3186553742 cites W2127257837 @default.
• W3186553742 cites W2140787893 @default.
• W3186553742 cites W2140871474 @default.
• W3186553742 cites W2152336072 @default.
• W3186553742 cites W2152625605 @default.
• W3186553742 cites W2154745198 @default.
• W3186553742 cites W2158218002 @default.
• W3186553742 cites W2164342861 @default.
• W3186553742 cites W2164959062 @default.
• W3186553742 cites W2165668731 @default.
• W3186553742 cites W2168921497 @default.
• W3186553742 cites W2171340584 @default.
• W3186553742 cites W2206558394 @default.
• W3186553742 cites W2252291791 @default.
• W3186553742 cites W2256831100 @default.
• W3186553742 cites W2292048640 @default.
• W3186553742 cites W2337492846 @default.
• W3186553742 cites W2345497697 @default.
• W3186553742 cites W2400938511 @default.
• W3186553742 cites W2526492644 @default.
• W3186553742 cites W2529737593 @default.
• W3186553742 cites W2595474555 @default.
• W3186553742 cites W2604153442 @default.
• W3186553742 cites W2609196293 @default.
• W3186553742 cites W2622568430 @default.
• W3186553742 cites W2736323777 @default.
• W3186553742 cites W2755483772 @default.
• W3186553742 cites W2762724683 @default.
• W3186553742 cites W2788695973 @default.
• W3186553742 cites W2799561642 @default.
• W3186553742 cites W2799891707 @default.
• W3186553742 cites W2852956162 @default.
• W3186553742 cites W2891257524 @default.
• W3186553742 cites W2897492348 @default.
• W3186553742 cites W2900352306 @default.
• W3186553742 cites W2906640926 @default.
• W3186553742 cites W2909701226 @default.
• W3186553742 cites W2913620138 @default.
• W3186553742 cites W2915375909 @default.
• W3186553742 cites W2922810409 @default.
• W3186553742 cites W2939522456 @default.
• W3186553742 cites W2953639947 @default.
• W3186553742 cites W2974174249 @default.
• W3186553742 cites W3000033244 @default.
• W3186553742 cites W3010334725 @default.
• W3186553742 cites W3025080937 @default.
• W3186553742 cites W3032916792 @default.
• W3186553742 cites W3096396220 @default.
• W3186553742 cites W3115730781 @default.
• W3186553742 cites W3163042948 @default.
• W3186553742 cites W49144085 @default.
• W3186553742 doi "https://doi.org/10.1159/000518274" @default.

• next