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- W3186558927 abstract "The COVID-19 pandemic has led to an unprecedented global health challenge, creating sudden, massive demands for diagnostic testing, treatment, therapies, and vaccines. In particular, the development of diagnostic assays for SARS-CoV-2 has been pursued as they are needed for quarantine, disease surveillance, and patient treatment. One of the major lessons the pandemic highlighted was the need for fast, cheap, scalable and reliable diagnostic methods, such as paper-based assays. Furthermore, it has previously been suggested that paper-based tests may be more suitable for settings with lower resource availability and may help alleviate some supply chain challenges which arose during the COVID-19 pandemic. Therefore, we explore how such devices may fit in a comprehensive diagnostic strategy and how some of the challenges to the technology, e.g. low sensitivity, may be addressed. We discuss the properties of the SARS-CoV-2 virus itself, the COVID-19 disease pathway, and the immune response. We then describe the different diagnostic strategies that have been pursued, focusing on molecular strategies for viral genetic material, antigen tests, and serological assays, and innovations for improving the diagnostic sensitivity and capabilities. Finally, we discuss pressing issues for the future, and what needs to be addressed for the ongoing pandemic and future outbreaks." @default.
- W3186558927 created "2021-08-02" @default.
- W3186558927 creator A5012832128 @default.
- W3186558927 creator A5013388497 @default.
- W3186558927 creator A5053568882 @default.
- W3186558927 creator A5064843606 @default.
- W3186558927 date "2021-01-01" @default.
- W3186558927 modified "2023-09-27" @default.
- W3186558927 title "SARS-CoV-2 and approaches for a testing and diagnostic strategy" @default.
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