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- W3186572052 endingPage "10620" @default.
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- W3186572052 abstract "Targeted protein degradation is a promising area in the discovery and development of innovative therapeutics. Molecular glues mediate proximity-induced protein degradation and have intrinsic advantages over heterobifunctional proteolysis-targeting chimeras, including unprecedented mechanisms, distinct biological activities, and favorable physicochemical properties. Classical molecular glue degraders have been identified serendipitously, but rational discovery and design strategies are emerging rapidly. In this review, we aim to highlight the recent advances in molecular glues for targeted protein degradation and discuss the challenges in developing molecular glues into therapeutic agents. In particular, discovery strategies, action mechanisms, and representative case studies will be addressed." @default.
- W3186572052 created "2021-08-02" @default.
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- W3186572052 date "2021-07-28" @default.
- W3186572052 modified "2023-10-14" @default.
- W3186572052 title "Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery" @default.
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- W3186572052 doi "https://doi.org/10.1021/acs.jmedchem.1c00895" @default.
- W3186572052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34319094" @default.
- W3186572052 hasPublicationYear "2021" @default.
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