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- W3186626158 abstract "Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a subtype of stiff-person syndrome (formerly stiff-man syndrome). It is rare and disabling, and characterised by brainstem symptoms, muscle stiffness, breathing issues and autonomic dysfunction. We describe a 65-year-old man who presented with odynophagia together with tongue and neck swelling, followed by multiple cranial nerve palsies culminating in bilateral vocal cord paralysis with acute stridor. He subsequently developed progressive generalised hypertonia and painful limb spasms. Serum antiglycine receptor antibody was strongly positive, but antiglutamic acid decarboxylase and other antibodies relating to stiff-person syndrome were negative. We diagnosed PERM and gave intravenous corticosteroids and immunoglobulins without benefit; however, following plasma exchange he has made a sustained improvement." @default.
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- W3186626158 date "2021-07-28" @default.
- W3186626158 modified "2023-09-23" @default.
- W3186626158 title "Progressive encephalomyelitis with rigidity and myoclonus (PERM)" @default.
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- W3186626158 doi "https://doi.org/10.1136/practneurol-2021-003087" @default.
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