FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186642092> ?p ?o ?g. }

• W3186642092 endingPage "1170" @default.
• W3186642092 startingPage "1159" @default.
• W3186642092 abstract "Copper complex has been gaining much attention in anticancer research as a targeted agent since cancer cells uptake more copper than non-cancerous cells. Our group synthesised a ternary copper complex, which is composed of 1,10-phenanthroline and tyrosine [Cu(phen)(L-tyr)Cl].3H20. These two payloads have been designed to cleave DNA and inhibit protein degradation system (proteasome) concurrently in cancer cells, making this copper complex a dual-target compound.The current study was carried out to investigate the mode of cell death and the role of autophagy induced by [Cu(phen)(L-tyr)Cl].3H20 in MCF-7 and MDA-MB-231 breast cancer cells.Growth inhibition of [Cu(phen)(L-tyr)Cl].3H20 towards MDA-MB-231 and human non-cancerous MCF10A breast cells was determined by MTT assay. Annexin-V-FITC/PI and cell cycle analysis were evaluated by flow cytometry. The expression of p53, Bax, caspase-9, caspase-7, caspase-3 and LC3 was determined using western blot analysis. The cells were then co-treated with hydroxychloroquine to ascertain the role of autophagy induced by [Cu(phen)(L-tyr)Cl].3H20.[Cu(phen)(L-tyr)Cl].3H20 inhibited the growth of cancer cells dose-dependently with less toxicity towards MCF10A cells. Additionally, [Cu(phen)(L-tyr)Cl].3H20 induced apoptosis and cell cycle arrest towards MCF-7 and MDA-MB-231 breast cancer cells possibly via regulation of p53, Bax, caspase-9, caspase-3 and capase-7. The expression of LC3II was upregulated in both cancer cell lines upon treatment with [Cu(phen)(L-tyr) Cl].3H20, indicating the induction of autophagy. Co-treatment with autophagy inhibitor hydroxychloroquine significantly enhanced growth inhibition of both cell lines, suggesting that autophagy induced by [Cu(phen)(L-tyr) Cl].3H20 in both breast cancer cells promoted cell survival.[Cu(phen)(L-tyr)Cl].3H20 holds great potential to be developed for breast cancer treatment." @default.
• W3186642092 created "2021-08-02" @default.
• W3186642092 creator A5008439835 @default.
• W3186642092 creator A5008604867 @default.
• W3186642092 creator A5022089104 @default.
• W3186642092 creator A5040891404 @default.
• W3186642092 creator A5043656025 @default.
• W3186642092 creator A5045276745 @default.
• W3186642092 creator A5047709293 @default.
• W3186642092 creator A5056760978 @default.
• W3186642092 creator A5060454892 @default.
• W3186642092 creator A5063150631 @default.
• W3186642092 creator A5073802671 @default.
• W3186642092 creator A5075957521 @default.
• W3186642092 creator A5083524378 @default.
• W3186642092 date "2022-04-01" @default.
• W3186642092 modified "2023-09-26" @default.
• W3186642092 title "Induction of Apoptosis and Autophagy by Ternary Copper Complex Towards Breast Cancer Cells" @default.
• W3186642092 cites W1169719024 @default.
• W3186642092 cites W1970848923 @default.
• W3186642092 cites W1974791367 @default.
• W3186642092 cites W1984883623 @default.
• W3186642092 cites W1988125845 @default.
• W3186642092 cites W2017068190 @default.
• W3186642092 cites W2040527477 @default.
• W3186642092 cites W2043575265 @default.
• W3186642092 cites W2052077889 @default.
• W3186642092 cites W2058198205 @default.
• W3186642092 cites W2068476548 @default.
• W3186642092 cites W2069414088 @default.
• W3186642092 cites W2069452349 @default.
• W3186642092 cites W2074240528 @default.
• W3186642092 cites W2079351077 @default.
• W3186642092 cites W2079852484 @default.
• W3186642092 cites W2087969446 @default.
• W3186642092 cites W2094803805 @default.
• W3186642092 cites W2096439168 @default.
• W3186642092 cites W2102368462 @default.
• W3186642092 cites W2106871481 @default.
• W3186642092 cites W2129658137 @default.
• W3186642092 cites W2157567077 @default.
• W3186642092 cites W2235577208 @default.
• W3186642092 cites W2326005020 @default.
• W3186642092 cites W2331341346 @default.
• W3186642092 cites W2333758468 @default.
• W3186642092 cites W2339724778 @default.
• W3186642092 cites W2365797089 @default.
• W3186642092 cites W2520136079 @default.
• W3186642092 cites W2551260758 @default.
• W3186642092 cites W2560836545 @default.
• W3186642092 cites W2570405642 @default.
• W3186642092 cites W2596329858 @default.
• W3186642092 cites W2600467452 @default.
• W3186642092 cites W2737712434 @default.
• W3186642092 cites W2738241641 @default.
• W3186642092 cites W2740775105 @default.
• W3186642092 cites W2768197901 @default.
• W3186642092 cites W2768768130 @default.
• W3186642092 cites W2772062014 @default.
• W3186642092 cites W2782411240 @default.
• W3186642092 cites W2792308604 @default.
• W3186642092 cites W2795139701 @default.
• W3186642092 cites W2795722021 @default.
• W3186642092 cites W2797771850 @default.
• W3186642092 cites W2799480631 @default.
• W3186642092 cites W2801816908 @default.
• W3186642092 cites W2803417751 @default.
• W3186642092 cites W2805124128 @default.
• W3186642092 cites W2806752994 @default.
• W3186642092 cites W2886893080 @default.
• W3186642092 cites W2889608418 @default.
• W3186642092 cites W2899871244 @default.
• W3186642092 cites W2901197092 @default.
• W3186642092 cites W2902556019 @default.
• W3186642092 cites W2904049988 @default.
• W3186642092 cites W2911718257 @default.
• W3186642092 cites W2923967596 @default.
• W3186642092 cites W2936614919 @default.
• W3186642092 cites W2949473906 @default.
• W3186642092 cites W2962531081 @default.
• W3186642092 cites W2967027601 @default.
• W3186642092 cites W2972499605 @default.
• W3186642092 cites W2980859235 @default.
• W3186642092 cites W2986890770 @default.
• W3186642092 cites W2988238922 @default.
• W3186642092 cites W2990940920 @default.
• W3186642092 cites W2995712298 @default.
• W3186642092 cites W3010284596 @default.
• W3186642092 cites W3034940782 @default.
• W3186642092 cites W3093593152 @default.
• W3186642092 cites W3096521890 @default.
• W3186642092 cites W3128646645 @default.
• W3186642092 cites W613972939 @default.
• W3186642092 doi "https://doi.org/10.2174/1871520621666210726132543" @default.
• W3186642092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34315396" @default.
• W3186642092 hasPublicationYear "2022" @default.
• W3186642092 type Work @default.
• W3186642092 sameAs 3186642092 @default.

• next