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- W3186646134 abstract "Epsilon toxin (Etx) is the most important virulence factor of type D C. perfringens in ruminants. The recombinant vaccines can be used against Etx intoxication. This study aimed to investigate the humoral immune responses of mice against a recombinant Lactobacillus casei which surface-expressed H 151 P mutant of Etx ( L. casei -ε) after oral and parenteral immunization routes. The protective immunity was determined by challenge with trypsin-activated Etx. Higher humoral immune responses were seen in parenterally vaccinated mice with Freund's-adjuvanted L. casei -ε than non-adjuvanted and negative controls ( P<0.05 ). In the oral immunized mice, L. casei -ε displayed a significant difference in IgG titres compared with the negative controls. Challenge results showed full protection of oral immunized mice against one and two MLDs, and partial protection against 10 MLD of the trypsin-activated Etx, whereas, the parenteral immunized mice only induced 75 % of protection against one MLD. This may be related to the appropriate immunity responses by L. casei -ε at the mucosal surfaces, which highlights the role of the oral immunization. Thus, L. casei -ε can be considered as an oral vaccine candidate against Etx intoxication and enterotoxaemia. • The histidine residue at position 151 is a determinant of epsilon toxin toxicity in vivo. • A genetic toxoid of epsilon toxin (Etx-H 151 P) was synthesized and transformed into L. casei. • Lactobacillus casei -ε induces immune responses after oral and parenteral immunizations. • Lactobacillus casei -ε induces protective immune responses after oral immunization. • Lactobacillus casei -ε is an oral vaccine candidate for type D enterotoxemia in ruminants." @default.
- W3186646134 created "2021-08-02" @default.
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- W3186646134 date "2021-09-01" @default.
- W3186646134 modified "2023-10-03" @default.
- W3186646134 title "Immunogenicity of a recombinant Lactobacillus casei, surface-expressed H151P mutant of Clostridium perfringens epsilon toxin and its protective responses in BALB/c mice" @default.
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- W3186646134 doi "https://doi.org/10.1016/j.toxicon.2021.07.013" @default.
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