FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186646516> ?p ?o ?g. }

• W3186646516 endingPage "1611" @default.
• W3186646516 startingPage "1611" @default.
• W3186646516 abstract "Helicobacter pylori is a highly prevalent and harmful gastrointestinal pathogen. Antibiotic resistance and biofilm complexity have led to a decrease in the cure rate. Probiotics are considered to be an adjuvant therapy for clinical Helicobacter pylori infections. However, there is no substantial explanation for the adjuvant role of probiotics on H. pylori biofilm. In this study, the effects of probiotics in combination with amoxicillin (AMX) and clarithromycin (CLR) on H. pylori biofilms were explored in vitro for the first time. The minimum inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC) for H. pylori was determined by the microbroth dilution method, and the plate counting method was used to determine the minimum biofilm removal concentration (MBEC) and survival rate for H. pylori biofilm. The biofilm structure was observed by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM), protein and polysaccharide contents in extracellular polymeric substances (EPS) were determined by the Bradford method and the phenol-sulfate method, respectively. The gene expression levels of cagA and vacA were evaluated by real-time qPCR. Among the ten H. pylori strains, the clinical strain 3192 showed the strongest film-forming ability, the 3192 biofilms significantly improved the resistance to AMX and CLR, and AMX and CLR showed antagonistic effects on planktonic 3192 cells. When the Lactobacillus salivarius LN12 cell-free supernatant (CFS) was in combination with AMX and CLR, the 3192 biofilm structure was destroyed to a greater extent than when separately; more biofilm biomass and protein in EPS was decreased; and the downregulation effect of the virulence gene vacA was also greater than that of single use. In this study, we suggest that the addition of LN12 to AMX and CLR may enhance the therapeutic effect of triple therapy, especially for the treatment of H. pylori biofilms." @default.
• W3186646516 created "2021-08-02" @default.
• W3186646516 creator A5022008215 @default.
• W3186646516 creator A5045470044 @default.
• W3186646516 date "2021-07-28" @default.
• W3186646516 modified "2023-09-26" @default.
• W3186646516 title "Effects of Lactobacillus salivarius LN12 in Combination with Amoxicillin and Clarithromycin on Helicobacter pylori Biofilm In Vitro" @default.
• W3186646516 cites W1556376361 @default.
• W3186646516 cites W1877027271 @default.
• W3186646516 cites W1938139711 @default.
• W3186646516 cites W1945796226 @default.
• W3186646516 cites W1975213539 @default.
• W3186646516 cites W1991102008 @default.
• W3186646516 cites W2001751680 @default.
• W3186646516 cites W2007302341 @default.
• W3186646516 cites W2014368385 @default.
• W3186646516 cites W2020584618 @default.
• W3186646516 cites W2042398310 @default.
• W3186646516 cites W2044995312 @default.
• W3186646516 cites W2096815681 @default.
• W3186646516 cites W2106146882 @default.
• W3186646516 cites W2113562905 @default.
• W3186646516 cites W2130207964 @default.
• W3186646516 cites W2133617878 @default.
• W3186646516 cites W2153165213 @default.
• W3186646516 cites W2162138323 @default.
• W3186646516 cites W2208317954 @default.
• W3186646516 cites W2298909804 @default.
• W3186646516 cites W2317946202 @default.
• W3186646516 cites W2345996245 @default.
• W3186646516 cites W2527848138 @default.
• W3186646516 cites W2531020181 @default.
• W3186646516 cites W2560668770 @default.
• W3186646516 cites W2589291207 @default.
• W3186646516 cites W2596075308 @default.
• W3186646516 cites W2607006457 @default.
• W3186646516 cites W2739778494 @default.
• W3186646516 cites W2742403807 @default.
• W3186646516 cites W2790522681 @default.
• W3186646516 cites W2800799562 @default.
• W3186646516 cites W2801158592 @default.
• W3186646516 cites W2802402702 @default.
• W3186646516 cites W2881320234 @default.
• W3186646516 cites W2903557462 @default.
• W3186646516 cites W2907165235 @default.
• W3186646516 cites W2910688944 @default.
• W3186646516 cites W2918315477 @default.
• W3186646516 cites W2919648024 @default.
• W3186646516 cites W2924081358 @default.
• W3186646516 cites W2932236219 @default.
• W3186646516 cites W2942296328 @default.
• W3186646516 cites W2949619145 @default.
• W3186646516 cites W2955053257 @default.
• W3186646516 cites W2962837704 @default.
• W3186646516 cites W2990562879 @default.
• W3186646516 cites W3000557152 @default.
• W3186646516 cites W3008557842 @default.
• W3186646516 cites W3010463498 @default.
• W3186646516 cites W3015045028 @default.
• W3186646516 cites W3033168209 @default.
• W3186646516 cites W3037893717 @default.
• W3186646516 cites W3044950713 @default.
• W3186646516 cites W3082589528 @default.
• W3186646516 cites W3111410269 @default.
• W3186646516 cites W3129228205 @default.
• W3186646516 cites W3130159011 @default.
• W3186646516 cites W4248704365 @default.
• W3186646516 doi "https://doi.org/10.3390/microorganisms9081611" @default.
• W3186646516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8399496" @default.
• W3186646516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34442690" @default.
• W3186646516 hasPublicationYear "2021" @default.
• W3186646516 type Work @default.
• W3186646516 sameAs 3186646516 @default.
• W3186646516 citedByCount "7" @default.
• W3186646516 countsByYear W31866465162022 @default.
• W3186646516 countsByYear W31866465162023 @default.
• W3186646516 crossrefType "journal-article" @default.
• W3186646516 hasAuthorship W3186646516A5022008215 @default.
• W3186646516 hasAuthorship W3186646516A5045470044 @default.
• W3186646516 hasBestOaLocation W31866465161 @default.
• W3186646516 hasConcept C129968341 @default.
• W3186646516 hasConcept C176947019 @default.
• W3186646516 hasConcept C185592680 @default.
• W3186646516 hasConcept C2776409635 @default.
• W3186646516 hasConcept C2776962512 @default.
• W3186646516 hasConcept C2779708577 @default.
• W3186646516 hasConcept C2780206646 @default.
• W3186646516 hasConcept C2780795924 @default.
• W3186646516 hasConcept C501593827 @default.
• W3186646516 hasConcept C523546767 @default.
• W3186646516 hasConcept C54355233 @default.
• W3186646516 hasConcept C58123911 @default.
• W3186646516 hasConcept C86803240 @default.
• W3186646516 hasConcept C89423630 @default.
• W3186646516 hasConceptScore W3186646516C129968341 @default.
• W3186646516 hasConceptScore W3186646516C176947019 @default.
• W3186646516 hasConceptScore W3186646516C185592680 @default.
• W3186646516 hasConceptScore W3186646516C2776409635 @default.

• next