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• W3186649462 endingPage "118496" @default.
• W3186649462 startingPage "118496" @default.
• W3186649462 abstract "A homogeneous polysaccharide, EJP90-1, was isolated from the leaves of E. japonica by hot water extraction in this study. EJP90-1 (7702 Da) was a heteropolysaccharide mainly consisting of →5)-linked-α-L-Araf-(1→, →4)-linked-β-D-Manp-(1→, →2,4)-linked-α-L-Rhap-(1→, →4)-linked-α-D-Xylp-(1→, →4)-linked-β-D-Galp-(1→, →2)-linked-β-D-Galp-(1→, →6)-linked-β-D-Glcp-(1→, α-D-Glcp-(4→, and t-linked-α-L-Araf. EJP90-1 was found to show moderate anti-tumor activity at the cellular level. In order to improve the anti-tumor activity and the potential applications of EJP90-1, a typical sodium selenite-nitric acid (Na2SeO3-HNO3) modification on EJP90-1 was carried out. X-ray photoelectron spectroscopy (XPS) and energy dispersive spectrometer (EDS) analysis confirmed that Se was successfully introduced into the polymer chain of EJP90-1. The subsequent in vitro cytotoxicity evaluation showed the selenylation modification derivative (EJP90-1-Se) possessed significant antiproliferative activity against cancer cells (HepG2 and A549 cells) through inducing cell apoptosis. The anti-tumor activity of EJP90-1-Se was further confirmed by zebrafish models, which inhibited the proliferation and migration of HepG2 cells and the angiogenesis." @default.
• W3186649462 created "2021-08-02" @default.
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• W3186649462 date "2021-12-01" @default.
• W3186649462 modified "2023-10-14" @default.
• W3186649462 title "Structure features, selenylation modification, and improved anti-tumor activity of a polysaccharide from Eriobotrya japonica" @default.
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• W3186649462 doi "https://doi.org/10.1016/j.carbpol.2021.118496" @default.
• W3186649462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34560937" @default.
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