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- W3186656688 abstract "Memory-guided social recognition identifies someone from previous encounters or experiences, but the mechanisms of social memory remain unclear. Here, we find that a short-term memory from experiencing a stranger mouse lasting under 30 min interval is essential for subsequent social recognition in mice, but that interval prolonged to hours by replacing the stranger mouse with a familiar littermate. Optogenetic silencing of dorsal CA1 neuronal activity during trials or inter-trial intervals disrupted short-term memory-guided social recognition, without affecting the ability of being sociable or long-term memory-guided social recognition. Postnatal knockdown or knockout of autism spectrum disorder (ASD)-associated phosphatase and tensin homolog ( PTEN ) gene in dorsal hippocampal CA1 similarly impaired neuronal firing rate in vitro and altered firing pattern during social recognition. These PTEN mice showed deficits in social recognition with stranger mouse rather than littermate and exhibited impairment in T-maze spontaneous alternation task for testing short-term spatial memory. Thus, we suggest that a temporal activity of dorsal CA1 neurons may underlie formation of short-term memory to be critical for organizing subsequent social recognition but that is possibly disrupted in ASD." @default.
- W3186656688 created "2021-08-02" @default.
- W3186656688 creator A5000562487 @default.
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- W3186656688 creator A5088503073 @default.
- W3186656688 creator A5090875147 @default.
- W3186656688 date "2021-07-15" @default.
- W3186656688 modified "2023-10-15" @default.
- W3186656688 title "A Temporal Activity of CA1 Neurons Underlying Short-Term Memory for Social Recognition Altered in PTEN Mouse Models of Autism Spectrum Disorder" @default.
- W3186656688 cites W1499352093 @default.
- W3186656688 cites W1501060173 @default.
- W3186656688 cites W1557470610 @default.
- W3186656688 cites W1573822259 @default.
- W3186656688 cites W1607045712 @default.
- W3186656688 cites W1722767087 @default.
- W3186656688 cites W1783929995 @default.
- W3186656688 cites W1846418424 @default.
- W3186656688 cites W1921473050 @default.
- W3186656688 cites W1955575446 @default.
- W3186656688 cites W1964948442 @default.
- W3186656688 cites W1975958074 @default.
- W3186656688 cites W1976989402 @default.
- W3186656688 cites W1977679887 @default.
- W3186656688 cites W1979305117 @default.
- W3186656688 cites W1981683953 @default.
- W3186656688 cites W1986287316 @default.
- W3186656688 cites W1986782185 @default.
- W3186656688 cites W1996851161 @default.
- W3186656688 cites W2002734542 @default.
- W3186656688 cites W2005583856 @default.
- W3186656688 cites W2008597980 @default.
- W3186656688 cites W2010474365 @default.
- W3186656688 cites W2010778459 @default.
- W3186656688 cites W2011029903 @default.
- W3186656688 cites W2011504521 @default.
- W3186656688 cites W2016411894 @default.
- W3186656688 cites W2017097994 @default.
- W3186656688 cites W2018302286 @default.
- W3186656688 cites W2021251123 @default.
- W3186656688 cites W2023976995 @default.
- W3186656688 cites W2025176554 @default.
- W3186656688 cites W2029465497 @default.
- W3186656688 cites W2031534534 @default.
- W3186656688 cites W2034462492 @default.
- W3186656688 cites W2035614948 @default.
- W3186656688 cites W2035845442 @default.
- W3186656688 cites W2041561096 @default.
- W3186656688 cites W2042099250 @default.
- W3186656688 cites W2047674796 @default.
- W3186656688 cites W2049511526 @default.
- W3186656688 cites W2049535404 @default.
- W3186656688 cites W2050001847 @default.
- W3186656688 cites W2050659319 @default.
- W3186656688 cites W2051005796 @default.
- W3186656688 cites W2054086319 @default.
- W3186656688 cites W2054315646 @default.
- W3186656688 cites W2057308155 @default.
- W3186656688 cites W2058884122 @default.
- W3186656688 cites W2058918256 @default.
- W3186656688 cites W2061491996 @default.
- W3186656688 cites W2064836594 @default.
- W3186656688 cites W2067684298 @default.
- W3186656688 cites W2069961692 @default.
- W3186656688 cites W2070900790 @default.
- W3186656688 cites W2071358265 @default.
- W3186656688 cites W2075277397 @default.
- W3186656688 cites W2078195513 @default.
- W3186656688 cites W2080700455 @default.
- W3186656688 cites W2085957678 @default.
- W3186656688 cites W2088908133 @default.
- W3186656688 cites W2088980332 @default.
- W3186656688 cites W2089074101 @default.
- W3186656688 cites W2090580324 @default.
- W3186656688 cites W2090724577 @default.
- W3186656688 cites W2091568968 @default.
- W3186656688 cites W2095256251 @default.
- W3186656688 cites W2096707172 @default.
- W3186656688 cites W2102837197 @default.
- W3186656688 cites W2103674001 @default.
- W3186656688 cites W2104064321 @default.
- W3186656688 cites W2104616895 @default.
- W3186656688 cites W2106085507 @default.
- W3186656688 cites W2106138734 @default.
- W3186656688 cites W2109002457 @default.
- W3186656688 cites W2109091674 @default.
- W3186656688 cites W2110724392 @default.
- W3186656688 cites W2112927743 @default.
- W3186656688 cites W2115997974 @default.
- W3186656688 cites W2116369968 @default.
- W3186656688 cites W2117977220 @default.
- W3186656688 cites W2121579477 @default.