Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186707979> ?p ?o ?g. }
- W3186707979 endingPage "2000034" @default.
- W3186707979 startingPage "2000034" @default.
- W3186707979 abstract "Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as differentiation and development, and of the cellular response to external perturbation through signaling pathways. In this review we focus on the role of TFs as a link between signaling pathways and gene regulation. Cell signaling tends to result in the modulation of a set of TFs that then lead to changes in the cell's transcriptional program. We highlight the molecular layers at which TF activity can be measured and the associated technical and conceptual challenges. These layers include post-translational modifications (PTMs) of the TF, regulation of TF binding to DNA through chromatin accessibility and epigenetics, and expression of target genes. We highlight that a large number of TFs are understudied in both signaling and gene regulation studies, and that our knowledge about known TF targets has a strong literature bias. We argue that TFs serve as a perfect bridge between the fields of gene regulation and signaling, and that separating these fields hinders our understanding of cell functions. Multi-omics approaches that measure multiple dimensions of TF activity are ideally suited to study the interplay of cell signaling and gene regulation using TFs as the anchor to link the two fields." @default.
- W3186707979 created "2021-08-02" @default.
- W3186707979 creator A5040426315 @default.
- W3186707979 creator A5045317851 @default.
- W3186707979 creator A5067492324 @default.
- W3186707979 creator A5072080329 @default.
- W3186707979 date "2021-08-09" @default.
- W3186707979 modified "2023-10-18" @default.
- W3186707979 title "Transcription factors: Bridge between cell signaling and gene regulation" @default.
- W3186707979 cites W1558122435 @default.
- W3186707979 cites W1602702667 @default.
- W3186707979 cites W1796801877 @default.
- W3186707979 cites W1964321121 @default.
- W3186707979 cites W1966327575 @default.
- W3186707979 cites W1971951267 @default.
- W3186707979 cites W1978279515 @default.
- W3186707979 cites W1982881824 @default.
- W3186707979 cites W1986411314 @default.
- W3186707979 cites W1986619463 @default.
- W3186707979 cites W1987122345 @default.
- W3186707979 cites W1989419347 @default.
- W3186707979 cites W1991476773 @default.
- W3186707979 cites W1995242599 @default.
- W3186707979 cites W1996868531 @default.
- W3186707979 cites W1997801717 @default.
- W3186707979 cites W1997868107 @default.
- W3186707979 cites W1999084705 @default.
- W3186707979 cites W2000189769 @default.
- W3186707979 cites W2001604240 @default.
- W3186707979 cites W2013156169 @default.
- W3186707979 cites W2022736304 @default.
- W3186707979 cites W2033169664 @default.
- W3186707979 cites W2033781392 @default.
- W3186707979 cites W2043274355 @default.
- W3186707979 cites W2043764521 @default.
- W3186707979 cites W2045362835 @default.
- W3186707979 cites W2047364731 @default.
- W3186707979 cites W2051225779 @default.
- W3186707979 cites W2056579761 @default.
- W3186707979 cites W2060654598 @default.
- W3186707979 cites W2061834804 @default.
- W3186707979 cites W2068379897 @default.
- W3186707979 cites W2072822958 @default.
- W3186707979 cites W2074964991 @default.
- W3186707979 cites W2078537140 @default.
- W3186707979 cites W2080403967 @default.
- W3186707979 cites W2082797919 @default.
- W3186707979 cites W2085299836 @default.
- W3186707979 cites W2088204347 @default.
- W3186707979 cites W2091285777 @default.
- W3186707979 cites W2095926488 @default.
- W3186707979 cites W2098412979 @default.
- W3186707979 cites W2103240113 @default.
- W3186707979 cites W2105757691 @default.
- W3186707979 cites W2111846924 @default.
- W3186707979 cites W2112673809 @default.
- W3186707979 cites W2122264952 @default.
- W3186707979 cites W2123106337 @default.
- W3186707979 cites W2124239534 @default.
- W3186707979 cites W2125987139 @default.
- W3186707979 cites W2127236662 @default.
- W3186707979 cites W2131144673 @default.
- W3186707979 cites W2132173287 @default.
- W3186707979 cites W2132623845 @default.
- W3186707979 cites W2135782451 @default.
- W3186707979 cites W2143991512 @default.
- W3186707979 cites W2147524392 @default.
- W3186707979 cites W2152121035 @default.
- W3186707979 cites W2156564520 @default.
- W3186707979 cites W2157523980 @default.
- W3186707979 cites W2158577092 @default.
- W3186707979 cites W2163896200 @default.
- W3186707979 cites W2167315449 @default.
- W3186707979 cites W2172133051 @default.
- W3186707979 cites W2259938310 @default.
- W3186707979 cites W2260708522 @default.
- W3186707979 cites W2337819340 @default.
- W3186707979 cites W2472255748 @default.
- W3186707979 cites W2481611869 @default.
- W3186707979 cites W2484335322 @default.
- W3186707979 cites W2487549822 @default.
- W3186707979 cites W2494960642 @default.
- W3186707979 cites W2581468399 @default.
- W3186707979 cites W2603000633 @default.
- W3186707979 cites W2604896358 @default.
- W3186707979 cites W2612467560 @default.
- W3186707979 cites W2616922646 @default.
- W3186707979 cites W2728797067 @default.
- W3186707979 cites W2750049634 @default.
- W3186707979 cites W2757234574 @default.
- W3186707979 cites W2760742318 @default.
- W3186707979 cites W2767749844 @default.
- W3186707979 cites W2767826728 @default.
- W3186707979 cites W2782454362 @default.
- W3186707979 cites W2783975438 @default.
- W3186707979 cites W2785792383 @default.
- W3186707979 cites W2787865536 @default.
- W3186707979 cites W2790023639 @default.