FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186709725> ?p ?o ?g. }

• W3186709725 endingPage "8506" @default.
• W3186709725 startingPage "8492" @default.
• W3186709725 abstract "A large body of emerging evidence has revealed the role of p38/MK2 and PI3K/Akt/GSK3β cascades in the orchestrating process of colitis. Rutin, a bioflavonoid present in many fruits and vegetables, has been recognized to offer therapeutic attributes in acute colitis. However, its role in chronic colitic condition has not yet been delineated in reference to p38/MK2 and PI3K/Akt/GSK3β signalling. The present investigation assessed the efficacy and underlying molecular mechanism of rutin in alleviating DSS-induced chronic colitis. The analysis of signalling pathways demonstrated the robust activation of PI3K/Akt/GSK3β/MAPKs/NF-κB and p38/MK2 in DSS-induced colitis in animals, which was efficiently alleviated following the rutin treatment. In silico studies indicated its target specificity with these pathways. Rutin administration markedly improved the disease activity score, colon length, goblet cell loss and compromised colon epithelial integrity in colitic mice. Decreased expression of oxi-inflammatory markers such as IgM, IgE, iNOS, ICAM-1, HO-1 and Th1/IL-10 cytokines ratios after treatment suggests its efficacy in regulating effector, regulatory and B cell homeostasis. Additionally, rutin demonstrated its role in restoring epithelial integrity by modulating the transcript levels of tight junction proteins, mucus-secreting proteins, epithelial cell proliferation and apoptosis. Treg expansion revealed that rutin supplementation also exhibits an immune regulatory potential and suppresses inflammatory aggravation mediated by adaptive immune responses. Overall, results indicate that the modulation of p38/MK2 and PI3K/Akt/GSK3β/NF-κB pathways by rutin represents a novel therapeutic approach in chronic colitis that help to curb dysregulated intestinal integrity, cytokine ratio and splenic Tregs." @default.
• W3186709725 created "2021-08-02" @default.
• W3186709725 creator A5019364580 @default.
• W3186709725 creator A5026467615 @default.
• W3186709725 creator A5038687014 @default.
• W3186709725 creator A5047412400 @default.
• W3186709725 date "2021-01-01" @default.
• W3186709725 modified "2023-10-10" @default.
• W3186709725 title "Rutin prevents inflammation-associated colon damage <i>via</i> inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3β/NF-κB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis" @default.
• W3186709725 cites W170138251 @default.
• W3186709725 cites W1822745879 @default.
• W3186709725 cites W1830972360 @default.
• W3186709725 cites W1867120196 @default.
• W3186709725 cites W1924215734 @default.
• W3186709725 cites W1962290230 @default.
• W3186709725 cites W1965437709 @default.
• W3186709725 cites W1978840408 @default.
• W3186709725 cites W2004367933 @default.
• W3186709725 cites W2007131189 @default.
• W3186709725 cites W2013030672 @default.
• W3186709725 cites W2021774266 @default.
• W3186709725 cites W2023929289 @default.
• W3186709725 cites W2025553815 @default.
• W3186709725 cites W2044375074 @default.
• W3186709725 cites W2052266489 @default.
• W3186709725 cites W2053261820 @default.
• W3186709725 cites W2062344492 @default.
• W3186709725 cites W2064991313 @default.
• W3186709725 cites W2085281012 @default.
• W3186709725 cites W2102859444 @default.
• W3186709725 cites W2109180151 @default.
• W3186709725 cites W2120136891 @default.
• W3186709725 cites W2125967107 @default.
• W3186709725 cites W2150843773 @default.
• W3186709725 cites W2161383908 @default.
• W3186709725 cites W2319211023 @default.
• W3186709725 cites W2491549472 @default.
• W3186709725 cites W2735527928 @default.
• W3186709725 cites W2791456383 @default.
• W3186709725 cites W2805331522 @default.
• W3186709725 cites W2904886317 @default.
• W3186709725 cites W2906783828 @default.
• W3186709725 cites W2944338511 @default.
• W3186709725 cites W2966528739 @default.
• W3186709725 cites W2980480015 @default.
• W3186709725 cites W2981011853 @default.
• W3186709725 cites W2981116485 @default.
• W3186709725 cites W3112685313 @default.
• W3186709725 doi "https://doi.org/10.1039/d1fo01557e" @default.
• W3186709725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34302158" @default.
• W3186709725 hasPublicationYear "2021" @default.
• W3186709725 type Work @default.
• W3186709725 sameAs 3186709725 @default.
• W3186709725 citedByCount "19" @default.
• W3186709725 countsByYear W31867097252022 @default.
• W3186709725 countsByYear W31867097252023 @default.
• W3186709725 crossrefType "journal-article" @default.
• W3186709725 hasAuthorship W3186709725A5019364580 @default.
• W3186709725 hasAuthorship W3186709725A5026467615 @default.
• W3186709725 hasAuthorship W3186709725A5038687014 @default.
• W3186709725 hasAuthorship W3186709725A5047412400 @default.
• W3186709725 hasConcept C203014093 @default.
• W3186709725 hasConcept C2775862500 @default.
• W3186709725 hasConcept C2775963812 @default.
• W3186709725 hasConcept C2776914184 @default.
• W3186709725 hasConcept C2778004101 @default.
• W3186709725 hasConcept C502942594 @default.
• W3186709725 hasConcept C51551487 @default.
• W3186709725 hasConcept C55493867 @default.
• W3186709725 hasConcept C57074206 @default.
• W3186709725 hasConcept C62478195 @default.
• W3186709725 hasConcept C71924100 @default.
• W3186709725 hasConcept C75217442 @default.
• W3186709725 hasConcept C86554907 @default.
• W3186709725 hasConcept C86803240 @default.
• W3186709725 hasConcept C95444343 @default.
• W3186709725 hasConcept C98274493 @default.
• W3186709725 hasConceptScore W3186709725C203014093 @default.
• W3186709725 hasConceptScore W3186709725C2775862500 @default.
• W3186709725 hasConceptScore W3186709725C2775963812 @default.
• W3186709725 hasConceptScore W3186709725C2776914184 @default.
• W3186709725 hasConceptScore W3186709725C2778004101 @default.
• W3186709725 hasConceptScore W3186709725C502942594 @default.
• W3186709725 hasConceptScore W3186709725C51551487 @default.
• W3186709725 hasConceptScore W3186709725C55493867 @default.
• W3186709725 hasConceptScore W3186709725C57074206 @default.
• W3186709725 hasConceptScore W3186709725C62478195 @default.
• W3186709725 hasConceptScore W3186709725C71924100 @default.
• W3186709725 hasConceptScore W3186709725C75217442 @default.
• W3186709725 hasConceptScore W3186709725C86554907 @default.
• W3186709725 hasConceptScore W3186709725C86803240 @default.
• W3186709725 hasConceptScore W3186709725C95444343 @default.
• W3186709725 hasConceptScore W3186709725C98274493 @default.
• W3186709725 hasFunder F4320320721 @default.
• W3186709725 hasFunder F4320334771 @default.
• W3186709725 hasIssue "18" @default.
• W3186709725 hasLocation W31867097251 @default.
• W3186709725 hasLocation W31867097252 @default.

• next