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• W3186713796 abstract "Reactivation of T-cell immunity by blocking the PD-1/PD-L1 immune checkpoint has been considered a promising strategy for cancer treatment. However, the recognition of PD-L1 by antibodies is usually suppressed due to the N-linked glycosylation of PD-L1. In this study, we present an effective PD-L1-blocking strategy based on a sialidase-conjugated NanoNiche to improve the antitumor effect via T-cell reactivation. Molecularly imprinted by PD-L1 N-glycans, NanoNiche can specifically recognize glycosylated PD-L1 on the tumor cell surface, thereby resulting in more efficient PD-L1 blockade. Moreover, sialidase modified on the surface of NanoNiche can selectively strip sialoglycans from tumor cells, enhancing immune cell infiltration. In vitro studies confirmed that NanoNiche can specifically bind with PD-L1 while also desialylate the tumor cell surface. The proliferation of PD-L1-positive MDA-MB-231 human breast cancer cells under T-cell killing was significantly inhibited after NanoNiche treatment. In vivo experiments in solid tumors show enhanced therapeutic efficacy. Thus, the NanoNiche-sialidase conjugate represents a promising approach for immune checkpoint blockade therapy." @default.
• W3186713796 created "2021-08-02" @default.
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• W3186713796 date "2021-07-02" @default.
• W3186713796 modified "2023-10-17" @default.
• W3186713796 title "Sialidase-Conjugated “NanoNiche” for Efficient Immune Checkpoint Blockade Therapy" @default.
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• W3186713796 doi "https://doi.org/10.1021/acsabm.1c00507" @default.
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• W3186713796 hasPublicationYear "2021" @default.
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