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- W3186757904 endingPage "737" @default.
- W3186757904 startingPage "725" @default.
- W3186757904 abstract "Psoriasis is a chronic, relapsing, immune-mediated systemic disease. Its pathogenesis is complex and not fully understood yet. Genetic and epigenetic factors interact with molecular pathways involving TNF-α, IL-23/IL-17 axis, and peculiar cytokines, as IL-36 or phosphodiesterase 4. This review discusses the mechanisms involved in the development of the disease, as well as the therapeutic options proposed following the investigation of the inflammatory psoriatic pathways. We performed a comprehensive search using the words and the newest molecules currently under investigation and approval. From these data, a new scenario in psoriasis is occurring to personalize the therapies - especially systemic ones and those using small molecules - and avoid topical and injectable drugs. We reported the newest therapeutic opportunities, including the inhibitors of Janus kinase/tyrosine kinase 2, phosphodiesterase-4 and IL-36 receptor. Today, more than 20 molecules are under investigation for the treatment of cutaneous psoriasis. Most of them are constituted by small molecules or biologic therapies. This underlines how psoriasis needs systemic therapies, due to its complex pathogenesis and multisystemic involvement." @default.
- W3186757904 created "2021-08-02" @default.
- W3186757904 creator A5002719929 @default.
- W3186757904 creator A5014765702 @default.
- W3186757904 creator A5041854258 @default.
- W3186757904 creator A5086252442 @default.
- W3186757904 creator A5086793471 @default.
- W3186757904 creator A5089821412 @default.
- W3186757904 date "2021-07-01" @default.
- W3186757904 modified "2023-10-17" @default.
- W3186757904 title "Experimental Pharmacological Management of Psoriasis" @default.
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