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- W3186819883 endingPage "764" @default.
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- W3186819883 abstract "Recent developments in genome editing and delivery systems have opened new possibilities for B cell gene therapy. CRISPR-Cas9 nucleases have been used to introduce transgenes into B cell genomes for subsequent secretion of exogenous therapeutic proteins from plasma cells and to program novel B cell Ag receptor specificities, allowing for the generation of desirable Ab responses that cannot normally be elicited in animal models. Genome modification of B cells or their progenitor, hematopoietic stem cells, could potentially substitute Ab or protein replacement therapies that require multiple injections over the long term. To date, B cell editing using CRISPR-Cas9 has been solely employed in preclinical studies, in which cells are edited ex vivo. In this review, we discuss current B cell engineering efforts and strategies for the eventual safe and economical adoption of modified B cells into the clinic, including in vivo viral delivery of editing reagents to B cells." @default.
- W3186819883 created "2021-08-02" @default.
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- W3186819883 creator A5022192348 @default.
- W3186819883 creator A5022987623 @default.
- W3186819883 creator A5060650805 @default.
- W3186819883 date "2021-07-28" @default.
- W3186819883 modified "2023-10-12" @default.
- W3186819883 title "Vector Strategies to Actualize B Cell–Based Gene Therapies" @default.
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