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- W3186848071 abstract "The liver is a key regulator of systemic energy homeostasis whose proper function is dependent on the circadian clock. Here, we show that livers deficient in the oscillator component JARID1a exhibit a dysregulation of genes involved in energy metabolism. Importantly, we find that mice that lack hepatic JARID1a have decreased lean body mass, decreased respiratory exchange ratios, faster production of ketones and increased glucose production in response to fasting. Finally, we find that JARID1a loss compromises the response of the hepatic transcriptome to nutrient availability. In all, ablation of hepatic JARID1a disrupts the coordination of hepatic metabolic programs with whole-body consequences." @default.
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- W3186848071 date "2018-01-01" @default.
- W3186848071 modified "2023-09-23" @default.
- W3186848071 title "Hepatic JARID1a Ablation Disrupts the Transcription Adaptation to Feeding and Alters Systemic Metabolism" @default.
- W3186848071 doi "https://doi.org/10.2139/ssrn.3307378" @default.
- W3186848071 hasPublicationYear "2018" @default.
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