FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186862313> ?p ?o ?g. }

• W3186862313 abstract "Neuromyelitis Optica Spectrum Disorder (NMOSD) is a demyelinating autoimmune disease of the central nervous system, more prevalent in individuals of non-European ancestry. Few studies have analyzed genetic risk factors in NMOSD, and HLA class II gene variation has been associated NMOSD risk in various populations including Mexicans. Thymopoietin ( TMPO ) has not been tested as a candidate gene for NMOSD or other autoimmune disease, however, experimental evidence suggests this gene may be involved in negative selection of autoreactive T cells and autoimmunity. We thus investigated whether the missense TMPO variant rs17028450 (Arg630Cys, frequent in Latin America) is associated with NMOSD, and whether this variant shows an interaction with HLA-class II rs9272219, previously associated with NMOSD risk. A total of 119 Mexican NMOSD patients, 1208 controls and 357 Native Mexican individuals were included. The HLA rs9272219 “T” risk allele frequency ranged from 21 to 68%, while the rs17028450 “T” minor allele frequency was as high as 18% in Native Mexican groups. Both rs9272219 and rs17028450 were significantly associated with NMOSD risk under additive models ( OR = 2.48; p = 8 × 10 –10 and OR = 1.59; p = 0.0075, respectively), and a significant interaction between both variants was identified with logistic regression models ( p = 0.048). Individuals bearing both risk alleles had an estimated 3.9-fold increased risk of NMOSD. To our knowledge, this is the first study reporting an association of TMPO gene variation with an autoimmune disorder and the interaction of specific susceptibility gene variants, that may contribute to the genetic architecture of NMOSD in admixed Latin American populations." @default.
• W3186862313 created "2021-08-02" @default.
• W3186862313 creator A5009861218 @default.
• W3186862313 creator A5010604563 @default.
• W3186862313 creator A5011054758 @default.
• W3186862313 creator A5013371455 @default.
• W3186862313 creator A5018285186 @default.
• W3186862313 creator A5021311480 @default.
• W3186862313 creator A5022266811 @default.
• W3186862313 creator A5024500349 @default.
• W3186862313 creator A5025350115 @default.
• W3186862313 creator A5040465902 @default.
• W3186862313 creator A5050004030 @default.
• W3186862313 creator A5068430534 @default.
• W3186862313 creator A5070407447 @default.
• W3186862313 creator A5082927643 @default.
• W3186862313 creator A5087463875 @default.
• W3186862313 date "2021-07-15" @default.
• W3186862313 modified "2023-10-18" @default.
• W3186862313 title "Interaction of HLA Class II rs9272219 and TMPO rs17028450 (Arg690Cys) Variants Affects Neuromyelitis Optica Spectrum Disorder Susceptibility in an Admixed Mexican Population" @default.
• W3186862313 cites W1570911802 @default.
• W3186862313 cites W1993222258 @default.
• W3186862313 cites W2005855288 @default.
• W3186862313 cites W2008871548 @default.
• W3186862313 cites W2011655967 @default.
• W3186862313 cites W2016375374 @default.
• W3186862313 cites W2026906110 @default.
• W3186862313 cites W2038370295 @default.
• W3186862313 cites W2039370859 @default.
• W3186862313 cites W2069068712 @default.
• W3186862313 cites W2073324575 @default.
• W3186862313 cites W2078567147 @default.
• W3186862313 cites W2131617184 @default.
• W3186862313 cites W2144469764 @default.
• W3186862313 cites W2149165622 @default.
• W3186862313 cites W2156654002 @default.
• W3186862313 cites W2170129323 @default.
• W3186862313 cites W2530131241 @default.
• W3186862313 cites W2578415684 @default.
• W3186862313 cites W2608171249 @default.
• W3186862313 cites W2758403056 @default.
• W3186862313 cites W2761092684 @default.
• W3186862313 cites W2792244548 @default.
• W3186862313 cites W2803456026 @default.
• W3186862313 cites W2809963516 @default.
• W3186862313 cites W2940277050 @default.
• W3186862313 cites W2944143053 @default.
• W3186862313 cites W3037214622 @default.
• W3186862313 cites W3044977941 @default.
• W3186862313 cites W3048465699 @default.
• W3186862313 cites W3062111874 @default.
• W3186862313 cites W3089314711 @default.
• W3186862313 cites W3106351625 @default.
• W3186862313 cites W4210660885 @default.
• W3186862313 cites W4234765472 @default.
• W3186862313 doi "https://doi.org/10.3389/fgene.2021.647343" @default.
• W3186862313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8320513" @default.
• W3186862313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34335680" @default.
• W3186862313 hasPublicationYear "2021" @default.
• W3186862313 type Work @default.
• W3186862313 sameAs 3186862313 @default.
• W3186862313 citedByCount "2" @default.
• W3186862313 countsByYear W31868623132022 @default.
• W3186862313 countsByYear W31868623132023 @default.
• W3186862313 crossrefType "journal-article" @default.
• W3186862313 hasAuthorship W3186862313A5009861218 @default.
• W3186862313 hasAuthorship W3186862313A5010604563 @default.
• W3186862313 hasAuthorship W3186862313A5011054758 @default.
• W3186862313 hasAuthorship W3186862313A5013371455 @default.
• W3186862313 hasAuthorship W3186862313A5018285186 @default.
• W3186862313 hasAuthorship W3186862313A5021311480 @default.
• W3186862313 hasAuthorship W3186862313A5022266811 @default.
• W3186862313 hasAuthorship W3186862313A5024500349 @default.
• W3186862313 hasAuthorship W3186862313A5025350115 @default.
• W3186862313 hasAuthorship W3186862313A5040465902 @default.
• W3186862313 hasAuthorship W3186862313A5050004030 @default.
• W3186862313 hasAuthorship W3186862313A5068430534 @default.
• W3186862313 hasAuthorship W3186862313A5070407447 @default.
• W3186862313 hasAuthorship W3186862313A5082927643 @default.
• W3186862313 hasAuthorship W3186862313A5087463875 @default.
• W3186862313 hasBestOaLocation W31868623131 @default.
• W3186862313 hasConcept C104317684 @default.
• W3186862313 hasConcept C118552586 @default.
• W3186862313 hasConcept C135763542 @default.
• W3186862313 hasConcept C147483822 @default.
• W3186862313 hasConcept C153209595 @default.
• W3186862313 hasConcept C157410074 @default.
• W3186862313 hasConcept C180754005 @default.
• W3186862313 hasConcept C186413461 @default.
• W3186862313 hasConcept C188280979 @default.
• W3186862313 hasConcept C203014093 @default.
• W3186862313 hasConcept C2777154362 @default.
• W3186862313 hasConcept C2780640218 @default.
• W3186862313 hasConcept C2781137167 @default.
• W3186862313 hasConcept C2908647359 @default.
• W3186862313 hasConcept C37463918 @default.
• W3186862313 hasConcept C54355233 @default.
• W3186862313 hasConcept C71924100 @default.
• W3186862313 hasConcept C86803240 @default.
• W3186862313 hasConcept C99454951 @default.

• next