FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186880212> ?p ?o ?g. }

• W3186880212 endingPage "105144" @default.
• W3186880212 startingPage "105144" @default.
• W3186880212 abstract "Cadmium is a widespread pollutant, which easily accumulates inside the human body with an estimated half-life of 25-30 years. Many data strongly suggest that it may play a role in the pathogenesis of neurodegenerative diseases. In this paper we investigated cadmium effect on human SH-SY5Y neuroblastoma cells metabolism. Results showed that, although SH-SY5Y cells already showed hyperactivated glycolysis, cadmium further increased basal glycolytic rate. Both glycolytic capacity and reserve were also increased following cadmium administration, endowing the cells with a higher compensatory glycolysis when oxidative phosphorylation was inhibited. Cadmium administration also led to an increase in glycolytic ATP production rate, paralleled by a decrease in ATP production by oxidative phosphorylation, due to an impairment of mitochondrial respiration. Moreover, following cadmium administration, mitochondria increased their dependency on glutamine, while decreasing lipids oxidation. On the whole, our data show that cadmium exacerbates the Warburg effect and promotes the use of glutamine as a substrate for lipid biosynthesis. Although increased glutamine consumption leads to an increase in glutathione level, this cannot efficiently counteract cadmium-induced oxidative stress, leading to membrane lipid peroxidation. Oxidative stress represents a serious threat for neuronal cells and our data confirm glutathione as a key defense mechanism." @default.
• W3186880212 created "2021-08-02" @default.
• W3186880212 creator A5001344541 @default.
• W3186880212 creator A5002354675 @default.
• W3186880212 creator A5008619281 @default.
• W3186880212 creator A5066220655 @default.
• W3186880212 creator A5071747756 @default.
• W3186880212 date "2021-10-01" @default.
• W3186880212 modified "2023-09-26" @default.
• W3186880212 title "Cadmium promotes glycolysis upregulation and glutamine dependency in human neuronal cells" @default.
• W3186880212 cites W1581414347 @default.
• W3186880212 cites W1590457525 @default.
• W3186880212 cites W1970658270 @default.
• W3186880212 cites W2005675003 @default.
• W3186880212 cites W2046582138 @default.
• W3186880212 cites W2051945227 @default.
• W3186880212 cites W2063931700 @default.
• W3186880212 cites W2076947999 @default.
• W3186880212 cites W2086215413 @default.
• W3186880212 cites W2092118074 @default.
• W3186880212 cites W2103953491 @default.
• W3186880212 cites W2158443083 @default.
• W3186880212 cites W2159518687 @default.
• W3186880212 cites W2336416528 @default.
• W3186880212 cites W2750368925 @default.
• W3186880212 cites W2769208006 @default.
• W3186880212 cites W2775452488 @default.
• W3186880212 cites W2911930516 @default.
• W3186880212 cites W2922546557 @default.
• W3186880212 cites W2937074474 @default.
• W3186880212 cites W2942864955 @default.
• W3186880212 cites W2965059230 @default.
• W3186880212 cites W2985590613 @default.
• W3186880212 cites W2991257989 @default.
• W3186880212 cites W3008488282 @default.
• W3186880212 cites W3032103849 @default.
• W3186880212 cites W3033624016 @default.
• W3186880212 cites W3119804279 @default.
• W3186880212 cites W3136023556 @default.
• W3186880212 cites W4293247451 @default.
• W3186880212 doi "https://doi.org/10.1016/j.neuint.2021.105144" @default.
• W3186880212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34303722" @default.
• W3186880212 hasPublicationYear "2021" @default.
• W3186880212 type Work @default.
• W3186880212 sameAs 3186880212 @default.
• W3186880212 citedByCount "6" @default.
• W3186880212 countsByYear W31868802122022 @default.
• W3186880212 countsByYear W31868802122023 @default.
• W3186880212 crossrefType "journal-article" @default.
• W3186880212 hasAuthorship W3186880212A5001344541 @default.
• W3186880212 hasAuthorship W3186880212A5002354675 @default.
• W3186880212 hasAuthorship W3186880212A5008619281 @default.
• W3186880212 hasAuthorship W3186880212A5066220655 @default.
• W3186880212 hasAuthorship W3186880212A5071747756 @default.
• W3186880212 hasConcept C109156525 @default.
• W3186880212 hasConcept C178790620 @default.
• W3186880212 hasConcept C181199279 @default.
• W3186880212 hasConcept C185592680 @default.
• W3186880212 hasConcept C20251656 @default.
• W3186880212 hasConcept C2776151105 @default.
• W3186880212 hasConcept C2779349466 @default.
• W3186880212 hasConcept C2780829032 @default.
• W3186880212 hasConcept C28859421 @default.
• W3186880212 hasConcept C515207424 @default.
• W3186880212 hasConcept C538909803 @default.
• W3186880212 hasConcept C544657597 @default.
• W3186880212 hasConcept C55493867 @default.
• W3186880212 hasConcept C57600042 @default.
• W3186880212 hasConcept C62231903 @default.
• W3186880212 hasConcept C86803240 @default.
• W3186880212 hasConcept C95444343 @default.
• W3186880212 hasConceptScore W3186880212C109156525 @default.
• W3186880212 hasConceptScore W3186880212C178790620 @default.
• W3186880212 hasConceptScore W3186880212C181199279 @default.
• W3186880212 hasConceptScore W3186880212C185592680 @default.
• W3186880212 hasConceptScore W3186880212C20251656 @default.
• W3186880212 hasConceptScore W3186880212C2776151105 @default.
• W3186880212 hasConceptScore W3186880212C2779349466 @default.
• W3186880212 hasConceptScore W3186880212C2780829032 @default.
• W3186880212 hasConceptScore W3186880212C28859421 @default.
• W3186880212 hasConceptScore W3186880212C515207424 @default.
• W3186880212 hasConceptScore W3186880212C538909803 @default.
• W3186880212 hasConceptScore W3186880212C544657597 @default.
• W3186880212 hasConceptScore W3186880212C55493867 @default.
• W3186880212 hasConceptScore W3186880212C57600042 @default.
• W3186880212 hasConceptScore W3186880212C62231903 @default.
• W3186880212 hasConceptScore W3186880212C86803240 @default.
• W3186880212 hasConceptScore W3186880212C95444343 @default.
• W3186880212 hasLocation W31868802121 @default.
• W3186880212 hasLocation W31868802122 @default.
• W3186880212 hasOpenAccess W3186880212 @default.
• W3186880212 hasPrimaryLocation W31868802121 @default.
• W3186880212 hasRelatedWork W2033929280 @default.
• W3186880212 hasRelatedWork W2070007419 @default.
• W3186880212 hasRelatedWork W2094706596 @default.
• W3186880212 hasRelatedWork W2101027575 @default.
• W3186880212 hasRelatedWork W2133486230 @default.
• W3186880212 hasRelatedWork W2315301857 @default.

• next