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• W3186890428 abstract "One of the most fundamental questions yet to be answered is how electrical stimulation patterns trigger neural networks in complex activation patterns and evoke somatosensory percepts. This chapter explores some historical landmarks in our search of this road map and ends with the state-of-the-art brain–machine interfaces, which are able to evoke both naturalistic proprioceptive and cutaneous sensations in human clinical trials. Starting with the discovery of electrical sensitivity of the brain in the 1800s, the authors explore the various animal models used to study how each parameter used in modern stimulation patterns influences reported sensations. Fundamental breakthroughs in electrical stimulation research with intracortical stimulation devices have rapidly accelerated in recent years, providing exciting new opportunities to deliver novel therapies to patients with a wide variety of disorders and diseases. Stimulation therapies have recently been approved to treat essential tremor, depression, and various psychiatric conditions. In addition, a wide range of new targets for stimulation has yielded tangible results: visual percepts, memory enhancement, and somatosensation on the arms, hands, head, and face. This exciting progress has been fueled by new collaborations between engineers designing novel stimulation devices, delivering ever more complex patterns to cortical targets, and by neuroscientists discovering cortical circuitry and understanding the networks responsible for processing sensation evoked by these stimulation patterns. This chapter lays the groundwork for understanding state-of-the-art stimulation pattern design and explains the current challenges yet to be tackled. By exploring these fundamental questions, the field can create assistive devices which feel naturalistic and enable device users to better experience the world around them." @default.
• W3186890428 created "2021-08-02" @default.
• W3186890428 creator A5046293778 @default.
• W3186890428 creator A5082264386 @default.
• W3186890428 date "2021-01-01" @default.
• W3186890428 modified "2023-09-25" @default.
• W3186890428 title "Design of intracortical microstimulation patterns to control the location, intensity, and quality of evoked sensations in human and animal models" @default.
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