FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3186965270> ?p ?o ?g. }

• W3186965270 endingPage "101072" @default.
• W3186965270 startingPage "101072" @default.
• W3186965270 abstract "Matrix metalloproteinase (MMP)-2 and MMP-9, also known as gelatinases or type IV collagenases, are recognized as major contributors to the proteolytic degradation of extracellular matrix during tumor invasion. Latent MMP-2 (proMMP-2) is activated by membrane type 1 MMP (MT1-MMP) on the cell surface of tumor cells. We previously reported that cell-bound proMMP-9 is activated by the MT1-MMP/MMP-2 axis in HT1080 cells treated with concanavalin A in the presence of exogenous proMMP-2. However, the regulatory mechanism of proMMP-9 activation remains largely unknown. Transforming growth factor (TGF)-β1 is frequently overexpressed in tumor tissues and is associated with tumor aggressiveness and poor prognosis. In this study, we examined the role of TGF-β1 on MT1-MMP-mediated proMMP-9 activation using human oral squamous cell carcinoma cells. TGF-β1 significantly increased the expression of MMP-9. By adding exogenous proMMP-2, TGF-β1-induced proMMP-9 was activated during collagen gel culture, which was suppressed by the inhibition of TGF-β1 signaling or MT1-MMP activity. This MT1-MMP-mediated proMMP-9 activation was needed to facilitate TGF-β1-induced cell invasion into collagen gel. Thus, TGF-β1 may facilitate MT1-MMP-mediated MMP-9 activation and thereby stimulate invasion of tumor cells in collaboration with MT1-MMP and MMP-2." @default.
• W3186965270 created "2021-08-02" @default.
• W3186965270 creator A5002280001 @default.
• W3186965270 creator A5021194200 @default.
• W3186965270 creator A5026980311 @default.
• W3186965270 creator A5062978118 @default.
• W3186965270 creator A5073945163 @default.
• W3186965270 creator A5077151260 @default.
• W3186965270 creator A5079767580 @default.
• W3186965270 date "2021-09-01" @default.
• W3186965270 modified "2023-10-18" @default.
• W3186965270 title "TGF-β1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells" @default.
• W3186965270 cites W1976831807 @default.
• W3186965270 cites W1979390430 @default.
• W3186965270 cites W2010254599 @default.
• W3186965270 cites W2010897615 @default.
• W3186965270 cites W2066365544 @default.
• W3186965270 cites W2075959628 @default.
• W3186965270 cites W2078344536 @default.
• W3186965270 cites W2083447892 @default.
• W3186965270 cites W2086641174 @default.
• W3186965270 cites W2086756946 @default.
• W3186965270 cites W2088402290 @default.
• W3186965270 cites W2090730788 @default.
• W3186965270 cites W2097648368 @default.
• W3186965270 cites W2112195516 @default.
• W3186965270 cites W2114666507 @default.
• W3186965270 cites W2119905596 @default.
• W3186965270 cites W2151846085 @default.
• W3186965270 cites W2153628853 @default.
• W3186965270 cites W2156656162 @default.
• W3186965270 cites W2438694140 @default.
• W3186965270 cites W2533114297 @default.
• W3186965270 cites W2565603936 @default.
• W3186965270 cites W2890887015 @default.
• W3186965270 cites W2904158224 @default.
• W3186965270 cites W3005326688 @default.
• W3186965270 cites W3047336807 @default.
• W3186965270 doi "https://doi.org/10.1016/j.bbrep.2021.101072" @default.
• W3186965270 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8339144" @default.
• W3186965270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34381878" @default.
• W3186965270 hasPublicationYear "2021" @default.
• W3186965270 type Work @default.
• W3186965270 sameAs 3186965270 @default.
• W3186965270 citedByCount "9" @default.
• W3186965270 countsByYear W31869652702021 @default.
• W3186965270 countsByYear W31869652702022 @default.
• W3186965270 countsByYear W31869652702023 @default.
• W3186965270 crossrefType "journal-article" @default.
• W3186965270 hasAuthorship W3186965270A5002280001 @default.
• W3186965270 hasAuthorship W3186965270A5021194200 @default.
• W3186965270 hasAuthorship W3186965270A5026980311 @default.
• W3186965270 hasAuthorship W3186965270A5062978118 @default.
• W3186965270 hasAuthorship W3186965270A5073945163 @default.
• W3186965270 hasAuthorship W3186965270A5077151260 @default.
• W3186965270 hasAuthorship W3186965270A5079767580 @default.
• W3186965270 hasBestOaLocation W31869652701 @default.
• W3186965270 hasConcept C109523444 @default.
• W3186965270 hasConcept C118131993 @default.
• W3186965270 hasConcept C137738243 @default.
• W3186965270 hasConcept C1491633281 @default.
• W3186965270 hasConcept C181199279 @default.
• W3186965270 hasConcept C185592680 @default.
• W3186965270 hasConcept C189165786 @default.
• W3186965270 hasConcept C2776232661 @default.
• W3186965270 hasConcept C2778394429 @default.
• W3186965270 hasConcept C2910246616 @default.
• W3186965270 hasConcept C502942594 @default.
• W3186965270 hasConcept C54355233 @default.
• W3186965270 hasConcept C55493867 @default.
• W3186965270 hasConcept C81885089 @default.
• W3186965270 hasConcept C86803240 @default.
• W3186965270 hasConcept C95444343 @default.
• W3186965270 hasConceptScore W3186965270C109523444 @default.
• W3186965270 hasConceptScore W3186965270C118131993 @default.
• W3186965270 hasConceptScore W3186965270C137738243 @default.
• W3186965270 hasConceptScore W3186965270C1491633281 @default.
• W3186965270 hasConceptScore W3186965270C181199279 @default.
• W3186965270 hasConceptScore W3186965270C185592680 @default.
• W3186965270 hasConceptScore W3186965270C189165786 @default.
• W3186965270 hasConceptScore W3186965270C2776232661 @default.
• W3186965270 hasConceptScore W3186965270C2778394429 @default.
• W3186965270 hasConceptScore W3186965270C2910246616 @default.
• W3186965270 hasConceptScore W3186965270C502942594 @default.
• W3186965270 hasConceptScore W3186965270C54355233 @default.
• W3186965270 hasConceptScore W3186965270C55493867 @default.
• W3186965270 hasConceptScore W3186965270C81885089 @default.
• W3186965270 hasConceptScore W3186965270C86803240 @default.
• W3186965270 hasConceptScore W3186965270C95444343 @default.
• W3186965270 hasFunder F4320318230 @default.
• W3186965270 hasFunder F4320318231 @default.
• W3186965270 hasFunder F4320320912 @default.
• W3186965270 hasLocation W31869652701 @default.
• W3186965270 hasLocation W31869652702 @default.
• W3186965270 hasLocation W31869652703 @default.
• W3186965270 hasOpenAccess W3186965270 @default.
• W3186965270 hasPrimaryLocation W31869652701 @default.
• W3186965270 hasRelatedWork W2004149502 @default.

• next