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• W3187008989 abstract "Shrews are small animals found in many different habitats. Like other mammals, adult neurogenesis occurs in the subventricular zone of the lateral ventricle (SVZ) and the dentate gyrus (DG) of the hippocampal formation. We asked whether the number of new generated cells in shrews depends on their brain size. We examined Crocidura russula and Neomys fodiens, weighing 10–22 g, and Crocidura olivieri and Suncus murinus that weigh three times more. We found that the density of proliferated cells in the SVZ was approximately at the same level in all species. These cells migrated from the SVZ through the rostral migratory stream to the olfactory bulb (OB). In this pathway, a low level of neurogenesis occurred in C. olivieri compared to three other species of shrews. In the DG, the rate of adult neurogenesis was regulated differently. Specifically, the lowest density of newly generated neurons was observed in C. russula, which had a substantial number of new neurons in the OB compared with C. olivieri. We suggest that the number of newly generated neurons in an adult shrew’s brain is independent of the brain size, and molecular mechanisms of neurogenesis appeared to be different in two neurogenic structures." @default.
• W3187008989 created "2021-08-02" @default.
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• W3187008989 date "2021-07-17" @default.
• W3187008989 modified "2023-10-16" @default.
• W3187008989 title "Effects of Brain Size on Adult Neurogenesis in Shrews" @default.
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• W3187008989 doi "https://doi.org/10.3390/ijms22147664" @default.
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• W3187008989 hasPublicationYear "2021" @default.
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