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- W3187029300 abstract "Abstract Upon SARS-CoV-2 infection, viral intermediates activate the Type I interferon (IFN) response through MDA5-mediated sensing and accordingly induce ADAR1 p150 expression, which might lead to A-to-I RNA editing of SARS-CoV-2. Here, we developed an RNA virus-specific editing identification pipeline, surveyed 7622 RNA-seq data from diverse types of samples infected with SARS-CoV-2, and constructed an atlas of A-to-I RNA editing sites in SARS-CoV-2. We found that A-to-I editing was dynamically regulated, and on average, approximately 91 editing events were deposited at viral dsRNA intermediates per sample. Moreover, editing hotspots were observed, including recoding sites in the spike gene that affect viral infectivity and antigenicity. Finally, we provided evidence that RNA editing accelerated SARS-CoV-2 evolution in humans. Collectively, our data suggest that SARS-CoV-2 hijacks components of the host antiviral machinery to edit its genome and fuel its evolution." @default.
- W3187029300 created "2021-08-02" @default.
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- W3187029300 date "2021-07-22" @default.
- W3187029300 modified "2023-10-16" @default.
- W3187029300 title "ADAR mediated A-to-I RNA editing affects SARS-CoV-2 characteristics and fuels its evolution" @default.
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- W3187029300 doi "https://doi.org/10.1101/2021.07.22.453345" @default.
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