Matches in SemOpenAlex for { <https://semopenalex.org/work/W3187029494> ?p ?o ?g. }
- W3187029494 endingPage "113900" @default.
- W3187029494 startingPage "113900" @default.
- W3187029494 abstract "The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA (saRNA) as a flexible immunotherapy platform to treat infectious diseases. Besides the antigen it encodes, mRNA itself has an immune-stimulating activity that can contribute to vaccine efficacy. This self-adjuvant effect, however, will interfere with mRNA translation and may influence the desired therapeutic outcome. To further exploit its potential as a versatile therapeutic platform, it will be crucial to control mRNA's innate immune-stimulating properties. In this regard, we describe the mechanisms behind the innate immune recognition of mRNA and provide an extensive overview of strategies to control its innate immune-stimulating activity. These strategies range from modifications to the mRNA backbone itself, optimization of production and purification processes to the combination with innate immune inhibitors. Furthermore, we discuss the delicate balance of the self-adjuvant effect in mRNA vaccination strategies, which can be both beneficial and detrimental to the therapeutic outcome." @default.
- W3187029494 created "2021-08-02" @default.
- W3187029494 creator A5001219220 @default.
- W3187029494 creator A5010359444 @default.
- W3187029494 creator A5015695983 @default.
- W3187029494 creator A5040375802 @default.
- W3187029494 creator A5048595477 @default.
- W3187029494 creator A5052529308 @default.
- W3187029494 creator A5066444032 @default.
- W3187029494 date "2021-09-01" @default.
- W3187029494 modified "2023-10-06" @default.
- W3187029494 title "Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across" @default.
- W3187029494 cites W1215958058 @default.
- W3187029494 cites W1267730164 @default.
- W3187029494 cites W1450336755 @default.
- W3187029494 cites W1484915017 @default.
- W3187029494 cites W1485002470 @default.
- W3187029494 cites W1529085705 @default.
- W3187029494 cites W1538766821 @default.
- W3187029494 cites W1560019489 @default.
- W3187029494 cites W1562702833 @default.
- W3187029494 cites W1582073699 @default.
- W3187029494 cites W1590760212 @default.
- W3187029494 cites W1608778557 @default.
- W3187029494 cites W1750553863 @default.
- W3187029494 cites W1781506009 @default.
- W3187029494 cites W1822930733 @default.
- W3187029494 cites W1909313221 @default.
- W3187029494 cites W1923876136 @default.
- W3187029494 cites W1931480957 @default.
- W3187029494 cites W1963706689 @default.
- W3187029494 cites W1963758675 @default.
- W3187029494 cites W1964795665 @default.
- W3187029494 cites W1965916060 @default.
- W3187029494 cites W1966865009 @default.
- W3187029494 cites W1967003781 @default.
- W3187029494 cites W1968573564 @default.
- W3187029494 cites W1969072247 @default.
- W3187029494 cites W1969544212 @default.
- W3187029494 cites W1981552958 @default.
- W3187029494 cites W1987968095 @default.
- W3187029494 cites W1989893709 @default.
- W3187029494 cites W1991064719 @default.
- W3187029494 cites W1994674548 @default.
- W3187029494 cites W1995580450 @default.
- W3187029494 cites W1995931397 @default.
- W3187029494 cites W1997873455 @default.
- W3187029494 cites W1997992792 @default.
- W3187029494 cites W2000174554 @default.
- W3187029494 cites W2000177767 @default.
- W3187029494 cites W2003316226 @default.
- W3187029494 cites W2004145685 @default.
- W3187029494 cites W2004586645 @default.
- W3187029494 cites W2006255127 @default.
- W3187029494 cites W2006652125 @default.
- W3187029494 cites W2006738527 @default.
- W3187029494 cites W2014495927 @default.
- W3187029494 cites W2016749309 @default.
- W3187029494 cites W2024266527 @default.
- W3187029494 cites W2025980739 @default.
- W3187029494 cites W2038139581 @default.
- W3187029494 cites W2038169247 @default.
- W3187029494 cites W2038813685 @default.
- W3187029494 cites W2039422212 @default.
- W3187029494 cites W2040653543 @default.
- W3187029494 cites W2041939573 @default.
- W3187029494 cites W2047967336 @default.
- W3187029494 cites W2050310145 @default.
- W3187029494 cites W2050843600 @default.
- W3187029494 cites W2054412308 @default.
- W3187029494 cites W2055976012 @default.
- W3187029494 cites W2058647478 @default.
- W3187029494 cites W2059126678 @default.
- W3187029494 cites W2059385530 @default.
- W3187029494 cites W2060696356 @default.
- W3187029494 cites W2066160869 @default.
- W3187029494 cites W2066847748 @default.
- W3187029494 cites W2070195233 @default.
- W3187029494 cites W2070751802 @default.
- W3187029494 cites W2071136305 @default.
- W3187029494 cites W2071302752 @default.
- W3187029494 cites W2072499238 @default.
- W3187029494 cites W2072569146 @default.
- W3187029494 cites W2072971665 @default.
- W3187029494 cites W2073435178 @default.
- W3187029494 cites W2075583438 @default.
- W3187029494 cites W2078844752 @default.
- W3187029494 cites W2079440368 @default.
- W3187029494 cites W2081360197 @default.
- W3187029494 cites W2082192685 @default.
- W3187029494 cites W2083228066 @default.
- W3187029494 cites W2084262527 @default.
- W3187029494 cites W2085272777 @default.
- W3187029494 cites W2087439897 @default.
- W3187029494 cites W2091129202 @default.
- W3187029494 cites W2093490741 @default.
- W3187029494 cites W2098419906 @default.
- W3187029494 cites W2098597036 @default.