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• W3187053723 startingPage "7883" @default.
• W3187053723 abstract "Proteins interact with many charged biological macromolecules (polyelectrolytes), including inorganic polyphosphates. Recently a new protein post-translational modification, polyphosphorylation, or a covalent binding of polyphosphate chain to lysine, was demonstrated in human and yeast. Herein, we performed the first molecular modeling study of a possible effect of polyphosphorylation on behavior of the modified protein using replica exchange molecular dynamics simulations in atomistic force field with explicit water. Human endoplasmin (GRP-94), a member of heat shock protein 90 family, was selected as a model protein. Intrinsically disordered region in N-terminal domain serving as a charged linker between domains and containing a polyacidic serine and lysine-rich motif, was selected as a potent polyphosphorylation site according to literature data. Polyphosphorylation, depending on exact modification site, has been shown to influence on the disordered loop flexibility and induce its further expanding, as well as induce changes in interaction with ordered part of the molecule. As a result, polyphosphorylation in N-terminal domain might affect interaction of HSP90 with client proteins since these chaperones play a key role in protein folding." @default.
• W3187053723 created "2021-08-02" @default.
• W3187053723 creator A5091525815 @default.
• W3187053723 date "2021-07-23" @default.
• W3187053723 modified "2023-10-15" @default.
• W3187053723 title "Effect of Polyphosphorylation on Behavior of Protein Disordered Regions" @default.
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• W3187053723 doi "https://doi.org/10.3390/ijms22157883" @default.
• W3187053723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8345927" @default.
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• W3187053723 hasPublicationYear "2021" @default.
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