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- W3187101400 endingPage "1018" @default.
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- W3187101400 abstract "Apoptosis, a major hallmark of cancer cells, regulates cellular fate and homeostasis. BCL-2 (B-cell CLL/Lymphoma 2) protein family is popularly known to mediate the intrinsic mode of apoptosis, of which MCL-1 is a crucial member. Myeloid cell leukemia 1 (MCL-1) is an anti-apoptotic oncoprotein and one of the most investigated members of the BCL-2 family. It is commonly known to be genetically altered, aberrantly overexpressed, and primarily associated with drug resistance in various human cancers. Recent advancements in the development of selective MCL-1 inhibitors and evaluating their effectiveness in cancer treatment establish its popularity as a molecular target. The overall aim is the selective induction of apoptosis in cancer cells by using a single or combination of BCL-2 family inhibitors. Delineating the precise molecular mechanisms associated with MCL-1-mediated cancer progression will certainly improve the efficacy of clinical interventions aimed at MCL-1 and hence patient survival. This review is structured to highlight the structural characteristics of MCL-1, its specific interactions with NOXA, MCL-1-regulatory microRNAs, and at the same time focus on the emerging therapeutic strategies targeting our protein of interest (MCL-1), alone or in combination with other treatments." @default.
- W3187101400 created "2021-08-16" @default.
- W3187101400 creator A5014870450 @default.
- W3187101400 creator A5015792394 @default.
- W3187101400 creator A5016885745 @default.
- W3187101400 creator A5020501260 @default.
- W3187101400 creator A5025224136 @default.
- W3187101400 creator A5090621653 @default.
- W3187101400 date "2021-09-01" @default.
- W3187101400 modified "2023-10-15" @default.
- W3187101400 title "Myeloid cell leukemia 1 (MCL-1): Structural characteristics and application in cancer therapy" @default.
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