FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3187165491> ?p ?o ?g. }

• W3187165491 endingPage "1459" @default.
• W3187165491 startingPage "1449" @default.
• W3187165491 abstract "Abstract Objective We investigated the cost‐effectiveness of three sequential prenatal cystic fibrosis (CF) carrier screening strategies: genotyping both partners, genotyping one partner then sequencing the second, and sequencing both partners. Method A decision‐analytic model compared the strategies in a theoretical cohort of four million pregnant couples in the US population and five racial/ethnic sub‐populations. Inputs were obtained from literature and varied in sensitivity analysis. Outcomes included cost per quality‐adjusted life year (QALY), missed carrier couples, affected newborns, missed prenatal diagnoses, terminations, and procedure‐related losses. The cost‐effectiveness threshold was $100,000/QALY. Results Sequencing both partners identified 1099 carrier couples that were missed by genotyping both partners, leading to 273 fewer missed prenatal diagnoses, 152 more terminations, and 152 fewer affected newborns. A similar trend was observed in the genotyping followed by sequencing strategy. The incremental cost‐effectiveness ratio of genotyping followed by sequencing compared to genotyping both partners was $180,004/QALY and the incremental cost‐effectiveness ratio of sequencing both partners compared to genotyping followed by sequencing was $17.6 million/QALY. Sequencing both partners was cost‐effective below $339 per test, genotyping/sequencing between $340 and $1837, and genotyping both partners above $1838. Sequencing was not cost‐effective among five racial/ethnic sub‐populations. Conclusion Despite improved outcomes, sequencing for prenatal CF carrier screening was not cost‐effective compared to genotyping. The clinical significance of the incremental cost‐effectiveness of CF carrier screening is a matter of deliberation for public policy debate." @default.
• W3187165491 created "2021-08-16" @default.
• W3187165491 creator A5006906657 @default.
• W3187165491 creator A5018600270 @default.
• W3187165491 creator A5060737880 @default.
• W3187165491 creator A5086404721 @default.
• W3187165491 date "2021-08-12" @default.
• W3187165491 modified "2023-10-17" @default.
• W3187165491 title "The cost‐effectiveness of genotyping versus sequencing for prenatal cystic fibrosis carrier screening" @default.
• W3187165491 cites W1964445496 @default.
• W3187165491 cites W1966074543 @default.
• W3187165491 cites W1968758950 @default.
• W3187165491 cites W1968991174 @default.
• W3187165491 cites W1975530489 @default.
• W3187165491 cites W1984147773 @default.
• W3187165491 cites W1998061484 @default.
• W3187165491 cites W2000278251 @default.
• W3187165491 cites W2015160508 @default.
• W3187165491 cites W2016206843 @default.
• W3187165491 cites W2034979275 @default.
• W3187165491 cites W2035140507 @default.
• W3187165491 cites W2039671670 @default.
• W3187165491 cites W2049205642 @default.
• W3187165491 cites W2049920356 @default.
• W3187165491 cites W2050102384 @default.
• W3187165491 cites W2055612477 @default.
• W3187165491 cites W2067343711 @default.
• W3187165491 cites W2089361076 @default.
• W3187165491 cites W2089619223 @default.
• W3187165491 cites W2116326069 @default.
• W3187165491 cites W2119672958 @default.
• W3187165491 cites W2130200560 @default.
• W3187165491 cites W2144946590 @default.
• W3187165491 cites W2166681647 @default.
• W3187165491 cites W2262795293 @default.
• W3187165491 cites W2582657518 @default.
• W3187165491 cites W2614452305 @default.
• W3187165491 cites W2773812517 @default.
• W3187165491 cites W2801750077 @default.
• W3187165491 cites W2943296634 @default.
• W3187165491 cites W2945069441 @default.
• W3187165491 cites W2949616890 @default.
• W3187165491 cites W4233819793 @default.
• W3187165491 doi "https://doi.org/10.1002/pd.6027" @default.
• W3187165491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34346064" @default.
• W3187165491 hasPublicationYear "2021" @default.
• W3187165491 type Work @default.
• W3187165491 sameAs 3187165491 @default.
• W3187165491 citedByCount "2" @default.
• W3187165491 countsByYear W31871654912023 @default.
• W3187165491 crossrefType "journal-article" @default.
• W3187165491 hasAuthorship W3187165491A5006906657 @default.
• W3187165491 hasAuthorship W3187165491A5018600270 @default.
• W3187165491 hasAuthorship W3187165491A5060737880 @default.
• W3187165491 hasAuthorship W3187165491A5086404721 @default.
• W3187165491 hasBestOaLocation W31871654911 @default.
• W3187165491 hasConcept C104317684 @default.
• W3187165491 hasConcept C112930515 @default.
• W3187165491 hasConcept C126322002 @default.
• W3187165491 hasConcept C131872663 @default.
• W3187165491 hasConcept C135763542 @default.
• W3187165491 hasConcept C158951850 @default.
• W3187165491 hasConcept C172680121 @default.
• W3187165491 hasConcept C2776938444 @default.
• W3187165491 hasConcept C2778258057 @default.
• W3187165491 hasConcept C2779234561 @default.
• W3187165491 hasConcept C3019080777 @default.
• W3187165491 hasConcept C31467283 @default.
• W3187165491 hasConcept C54355233 @default.
• W3187165491 hasConcept C71924100 @default.
• W3187165491 hasConcept C86803240 @default.
• W3187165491 hasConceptScore W3187165491C104317684 @default.
• W3187165491 hasConceptScore W3187165491C112930515 @default.
• W3187165491 hasConceptScore W3187165491C126322002 @default.
• W3187165491 hasConceptScore W3187165491C131872663 @default.
• W3187165491 hasConceptScore W3187165491C135763542 @default.
• W3187165491 hasConceptScore W3187165491C158951850 @default.
• W3187165491 hasConceptScore W3187165491C172680121 @default.
• W3187165491 hasConceptScore W3187165491C2776938444 @default.
• W3187165491 hasConceptScore W3187165491C2778258057 @default.
• W3187165491 hasConceptScore W3187165491C2779234561 @default.
• W3187165491 hasConceptScore W3187165491C3019080777 @default.
• W3187165491 hasConceptScore W3187165491C31467283 @default.
• W3187165491 hasConceptScore W3187165491C54355233 @default.
• W3187165491 hasConceptScore W3187165491C71924100 @default.
• W3187165491 hasConceptScore W3187165491C86803240 @default.
• W3187165491 hasIssue "11" @default.
• W3187165491 hasLocation W31871654911 @default.
• W3187165491 hasLocation W31871654912 @default.
• W3187165491 hasOpenAccess W3187165491 @default.
• W3187165491 hasPrimaryLocation W31871654911 @default.
• W3187165491 hasRelatedWork W157860531 @default.
• W3187165491 hasRelatedWork W1966074543 @default.
• W3187165491 hasRelatedWork W2001028994 @default.
• W3187165491 hasRelatedWork W2020503567 @default.
• W3187165491 hasRelatedWork W2049460266 @default.
• W3187165491 hasRelatedWork W2067811233 @default.
• W3187165491 hasRelatedWork W2110374842 @default.

• next