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- W3187225365 abstract "Abstract The number of animals killed used for research purposes has increased significantly in recent years. For this reason, several alternatives of animal models are widely used. In this study, two phases of calcium phosphates synthesized by the sol-gel method were added by precipitation to the surface of the natural rubber latex membranes for bone applications. Membranes cytotoxicity and toxicity was evaluated by in vitro and in vivo methods. Hemolysis levels were less than 3%, which indicates that there was no significant hemolytic activity. It was demonstrated that latex presents enzymes that can dissociate osteoblasts MC3T3, so it was necessary to eliminate these enzymes to obtain a good adhesion and cellular proliferation without morphological alterations. The in vivo toxicity test with Caenorhabditis elegans worms did not show evidence of toxicity with a sample of hydroxyapatite incubated for 5 days, exhibiting the lowest survival rate of the worms. In the Zebrafish embryotoxicity assay, 60% of embryos survived and there was no evidence of embryos with malformation or developmental delay. In summary, alternative animal models, which are not commonly used to assess biocompatibility, have provided reliable in vivo results that allow suggesting the use of these membranes in the bone biomedical." @default.
- W3187225365 created "2021-08-16" @default.
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- W3187225365 date "2021-07-19" @default.
- W3187225365 modified "2023-10-18" @default.
- W3187225365 title "Use of Caenorhabditis Elegans and Zebrafish Embryo as an Alternative Model for Biocompatibility Assessment of Natural Latex Biocomposite" @default.
- W3187225365 doi "https://doi.org/10.21203/rs.3.rs-708923/v1" @default.
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