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- W3187286782 abstract "SUMMARY In contracting striated muscle titin acts as a spring in parallel with the array of myosin motors in each half-sarcomere and could prevent the intrinsic instability of thousands of serially linked half-sarcomeres, if its stiffness, at physiological sarcomere lengths (SL), were ten times larger than reported. Here we define titin mechanical properties during tetanic stimulation of single fibres of frog muscle by suppressing myosin motor responses with Para-Nitro-Blebbistatin, which is able to freeze thick filament in the resting state. We discover that thin filament activation switches I-band titin spring from the large SL-dependent extensibility of the OFF-state to an ON-state in which titin acts as a SL-independent mechanical rectifier, allowing free shortening while opposing stretch with an effective stiffness 4 pN nm −1 per half-thick filament. In this way during contraction titin limits weak half-sarcomere elongation to a few % and, also, provides an efficient link for mechanosensing-based thick filament activation." @default.
- W3187286782 created "2021-08-16" @default.
- W3187286782 creator A5003324996 @default.
- W3187286782 creator A5019972094 @default.
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- W3187286782 creator A5025730785 @default.
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- W3187286782 creator A5036424978 @default.
- W3187286782 creator A5046717949 @default.
- W3187286782 creator A5047123316 @default.
- W3187286782 date "2021-08-09" @default.
- W3187286782 modified "2023-10-15" @default.
- W3187286782 title "Titin switches from an extensible spring to a mechanical rectifier upon muscle activation" @default.
- W3187286782 cites W138607898 @default.
- W3187286782 cites W139544104 @default.
- W3187286782 cites W1509188373 @default.
- W3187286782 cites W1542208611 @default.
- W3187286782 cites W1568873043 @default.
- W3187286782 cites W1669455160 @default.
- W3187286782 cites W1901823973 @default.
- W3187286782 cites W1974292756 @default.
- W3187286782 cites W1977378217 @default.
- W3187286782 cites W1980685237 @default.
- W3187286782 cites W1981648311 @default.
- W3187286782 cites W1982133638 @default.
- W3187286782 cites W1992121070 @default.
- W3187286782 cites W1995886943 @default.
- W3187286782 cites W1997246410 @default.
- W3187286782 cites W2003233440 @default.
- W3187286782 cites W2009582775 @default.
- W3187286782 cites W2014574071 @default.
- W3187286782 cites W2016827534 @default.
- W3187286782 cites W2017248441 @default.
- W3187286782 cites W2017449223 @default.
- W3187286782 cites W2018436504 @default.
- W3187286782 cites W2019690260 @default.
- W3187286782 cites W2031383670 @default.
- W3187286782 cites W2031792977 @default.
- W3187286782 cites W2033867498 @default.
- W3187286782 cites W2039688546 @default.
- W3187286782 cites W2040530969 @default.
- W3187286782 cites W2042110079 @default.
- W3187286782 cites W2046104659 @default.
- W3187286782 cites W2046584177 @default.
- W3187286782 cites W2051760300 @default.
- W3187286782 cites W2058581358 @default.
- W3187286782 cites W2058912578 @default.
- W3187286782 cites W2061959498 @default.
- W3187286782 cites W2065409477 @default.
- W3187286782 cites W2067440334 @default.
- W3187286782 cites W2070037836 @default.
- W3187286782 cites W2070929467 @default.
- W3187286782 cites W2071156256 @default.
- W3187286782 cites W2071181961 @default.
- W3187286782 cites W2078493606 @default.
- W3187286782 cites W2083793523 @default.
- W3187286782 cites W2084839420 @default.
- W3187286782 cites W2089158948 @default.
- W3187286782 cites W2090191667 @default.
- W3187286782 cites W2093537924 @default.
- W3187286782 cites W2095554109 @default.
- W3187286782 cites W2100968871 @default.
- W3187286782 cites W2102071784 @default.
- W3187286782 cites W2109148186 @default.
- W3187286782 cites W2115228561 @default.
- W3187286782 cites W2118202513 @default.
- W3187286782 cites W2126468848 @default.
- W3187286782 cites W2127917887 @default.
- W3187286782 cites W2131202031 @default.
- W3187286782 cites W2133061669 @default.
- W3187286782 cites W2137471276 @default.
- W3187286782 cites W2139106132 @default.
- W3187286782 cites W2139716783 @default.
- W3187286782 cites W2139889188 @default.
- W3187286782 cites W2149218119 @default.
- W3187286782 cites W2153177273 @default.
- W3187286782 cites W2155664915 @default.
- W3187286782 cites W2169400659 @default.
- W3187286782 cites W2169949242 @default.
- W3187286782 cites W2171711521 @default.
- W3187286782 cites W2172039086 @default.
- W3187286782 cites W2175091017 @default.
- W3187286782 cites W2191896778 @default.
- W3187286782 cites W2272949511 @default.
- W3187286782 cites W2419337888 @default.
- W3187286782 cites W2537119940 @default.
- W3187286782 cites W2545141121 @default.
- W3187286782 cites W2627019530 @default.
- W3187286782 cites W2769293916 @default.
- W3187286782 cites W2801612079 @default.
- W3187286782 cites W2805397392 @default.
- W3187286782 cites W2890446853 @default.
- W3187286782 cites W2891626555 @default.
- W3187286782 cites W2894229977 @default.
- W3187286782 cites W2920379114 @default.
- W3187286782 cites W2949955321 @default.
- W3187286782 cites W2993266200 @default.
- W3187286782 cites W3134245784 @default.
- W3187286782 cites W3146761022 @default.