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• W3187295349 startingPage "1673" @default.
• W3187295349 abstract "With dexamethasone as the model drug and polycaprolactone (PCL) as the carrier material, a drug delivery coating for cochlear electrodes was prepared, to control cochlear fibrosis caused by cochlear implantation. A dexamethasone/poly (ε-caprolactone)-based electrode coating was prepared using the impregnation coating method. Preparation parameters were optimized, yielding 1 impregnation instance, impregnation time of 10 s, and PCL concentration of 10%. The coating was characterized in vitro using scanning electron microscopy, a universal machine, high-performance liquid chromatography, and CCK-8. The surface was porous and uniformly thick (average thickness, 48.67 µm)-with good flexibility, long-term slow drug release, and optimal drug concentration-and was biologically safe. The experimental results show that PCL is an ideal controlled-release material for dexamethasone as a drug carrier coating for cochlear implants." @default.
• W3187295349 created "2021-08-16" @default.
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• W3187295349 date "2021-01-01" @default.
• W3187295349 modified "2023-10-12" @default.
• W3187295349 title "Preparation, characterization, and <i>in vitro</i>/<i>vivo</i> evaluation of dexamethasone/poly(ε-caprolactone)-based electrode coatings for cochlear implants" @default.
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• W3187295349 doi "https://doi.org/10.1080/10717544.2021.1960927" @default.
• W3187295349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8344245" @default.
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