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- W3187441381 abstract "The ongoing COVID-19 global pandemic caused by SARS-CoV-2 inspires the development of effective inhibitors to block the SARS-CoV-2 spike–ACE2 interaction. A chemical investigation on the fruiting bodies of Phellinus pini led to the isolation of five aromatic cadinane sesquiterpenoids including four new ones, named piniterpenoids A–D (1–4), as well as three known lignans. Their structures were determined by extensive spectroscopic analysis including HRMS and 1D and 2D NMR. All of the aromatic cadinane sesquiterpenoids inhibited the SARS-CoV-2 spike–ACE2 interaction, with IC50 values ranging from 64.5 to 99.1 μM. A molecular docking study showed the disruption of the interaction of compound 1 via hydrogen interactions with Arg403, Asp405, and Arg408 of SARS-CoV-2 RBD and Arg393 and His34 residues of ACE2. These results suggested that aromatic cadinane sesquiterpenoids might be useful in developing agents for COVID-19." @default.
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- W3187441381 date "2021-08-05" @default.
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- W3187441381 title "Aromatic Cadinane Sesquiterpenoids from the Fruiting Bodies of <i>Phellinus pini</i> Block SARS-CoV-2 Spike–ACE2 Interaction" @default.
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- W3187441381 doi "https://doi.org/10.1021/acs.jnatprod.1c00426" @default.
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