Matches in SemOpenAlex for { <https://semopenalex.org/work/W3187441469> ?p ?o ?g. }
- W3187441469 abstract "Osteoarthritis (OA) is a degenerative joint disease that causes a variety of adverse health effects. Considering the need to identify additional effective therapeutic options for OA therapy, we investigated the effect of co-injection of apigenin and synovial membrane-derived mesenchymal stem cells (SMMSCs) on OA in male rats' knee joints.The study was performed in 2019 at the Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran. Anterior cruciate ligament transection (ACLT) was used to induce OA. For three weeks, male Sprague-Dawley rats (eight groups, n=6 each) were treated once-weekly with intra-articular injections of apigenin alone or in combination with SMMSC (three million cells), phosphate-buffered saline, or hyaluronic acid. After three months, the interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), superoxide dismutase (SOD), and malondialdehyde (MDA) levels were measured in the cartilage homogenate. The expression of extracellular matrix (ECM) components including collagen 2a1, aggrecan, IL-1β, TNF-α, inducible nitric oxide synthase (iNOS), transcription factor SOX-9, and matrix metalloproteinases 3 and 13 were assessed using real-time polymerase chain reaction (RT-PCR) analysis. Radiological evaluation and histopathological assessment were used to evaluate the knees.Levels of TNF-α (P=0.009), MDA (P>0.001), and IL-1β (P<0.001) decreased and the level of SOD increased (P=0.004) in the apigenin 0.3 µM with SMMSCs group. RT-PCR analysis indicated that IL-1β in the apigenin 0.3 µM with SMMSCs group reduced significantly (P<0.001). This group also exhibited increased expression levels of SOX-9, collagen 2a1, and aggrecan (P<0.001).Apigenin may have supplementary beneficial effects on cell therapy in a rat model of OA due to its possible effect on the reduction of oxidative stress, suppression of inflammation, and promotion of production of ECM components." @default.
- W3187441469 created "2021-08-16" @default.
- W3187441469 creator A5011091244 @default.
- W3187441469 creator A5015241985 @default.
- W3187441469 creator A5040535268 @default.
- W3187441469 creator A5047218711 @default.
- W3187441469 creator A5047770124 @default.
- W3187441469 creator A5064585849 @default.
- W3187441469 date "2021-09-01" @default.
- W3187441469 modified "2023-09-23" @default.
- W3187441469 title "Efficacy of Combination Therapy with Apigenin and Synovial Membrane-Derived Mesenchymal Stem Cells on Knee Joint Osteoarthritis in a Rat Model." @default.
- W3187441469 cites W103910462 @default.
- W3187441469 cites W1594087984 @default.
- W3187441469 cites W1790126255 @default.
- W3187441469 cites W198269817 @default.
- W3187441469 cites W1988188434 @default.
- W3187441469 cites W1989148667 @default.
- W3187441469 cites W1992935708 @default.
- W3187441469 cites W1995122819 @default.
- W3187441469 cites W1995659229 @default.
- W3187441469 cites W2025371271 @default.
- W3187441469 cites W2038857063 @default.
- W3187441469 cites W2076045161 @default.
- W3187441469 cites W2076963888 @default.
- W3187441469 cites W2082954333 @default.
- W3187441469 cites W2083256869 @default.
- W3187441469 cites W2099427592 @default.
- W3187441469 cites W2107277218 @default.
- W3187441469 cites W2135763340 @default.
- W3187441469 cites W2146548807 @default.
- W3187441469 cites W2152602712 @default.
- W3187441469 cites W2164993228 @default.
- W3187441469 cites W2166592703 @default.
- W3187441469 cites W2235731915 @default.
- W3187441469 cites W2262385457 @default.
- W3187441469 cites W2323607810 @default.
- W3187441469 cites W2555068997 @default.
- W3187441469 cites W2562348685 @default.
- W3187441469 cites W2593927181 @default.
- W3187441469 cites W2610786526 @default.
- W3187441469 cites W2726121826 @default.
- W3187441469 cites W2735940883 @default.
- W3187441469 cites W2789872440 @default.
- W3187441469 cites W2913315260 @default.
- W3187441469 cites W2951905322 @default.
- W3187441469 cites W2956412540 @default.
- W3187441469 cites W828654849 @default.
- W3187441469 doi "https://doi.org/10.30476/ijms.2020.83686.1301" @default.
- W3187441469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8438345" @default.
- W3187441469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34539013" @default.
- W3187441469 hasPublicationYear "2021" @default.
- W3187441469 type Work @default.
- W3187441469 sameAs 3187441469 @default.
- W3187441469 citedByCount "4" @default.
- W3187441469 countsByYear W31874414692022 @default.
- W3187441469 crossrefType "journal-article" @default.
- W3187441469 hasAuthorship W3187441469A5011091244 @default.
- W3187441469 hasAuthorship W3187441469A5015241985 @default.
- W3187441469 hasAuthorship W3187441469A5040535268 @default.
- W3187441469 hasAuthorship W3187441469A5047218711 @default.
- W3187441469 hasAuthorship W3187441469A5047770124 @default.
- W3187441469 hasAuthorship W3187441469A5064585849 @default.
- W3187441469 hasConcept C105702510 @default.
- W3187441469 hasConcept C109523444 @default.
- W3187441469 hasConcept C126322002 @default.
- W3187441469 hasConcept C141071460 @default.
- W3187441469 hasConcept C142724271 @default.
- W3187441469 hasConcept C17991360 @default.
- W3187441469 hasConcept C185592680 @default.
- W3187441469 hasConcept C197534660 @default.
- W3187441469 hasConcept C198826908 @default.
- W3187441469 hasConcept C204787440 @default.
- W3187441469 hasConcept C2775838275 @default.
- W3187441469 hasConcept C2776151105 @default.
- W3187441469 hasConcept C2776164576 @default.
- W3187441469 hasConcept C2777077863 @default.
- W3187441469 hasConcept C2777529286 @default.
- W3187441469 hasConcept C2777622882 @default.
- W3187441469 hasConcept C2777652487 @default.
- W3187441469 hasConcept C2778004101 @default.
- W3187441469 hasConcept C2778232976 @default.
- W3187441469 hasConcept C2778401633 @default.
- W3187441469 hasConcept C2778434673 @default.
- W3187441469 hasConcept C2778609962 @default.
- W3187441469 hasConcept C2779054382 @default.
- W3187441469 hasConcept C2780550940 @default.
- W3187441469 hasConcept C3020332539 @default.
- W3187441469 hasConcept C519581460 @default.
- W3187441469 hasConcept C55493867 @default.
- W3187441469 hasConcept C71924100 @default.
- W3187441469 hasConceptScore W3187441469C105702510 @default.
- W3187441469 hasConceptScore W3187441469C109523444 @default.
- W3187441469 hasConceptScore W3187441469C126322002 @default.
- W3187441469 hasConceptScore W3187441469C141071460 @default.
- W3187441469 hasConceptScore W3187441469C142724271 @default.
- W3187441469 hasConceptScore W3187441469C17991360 @default.
- W3187441469 hasConceptScore W3187441469C185592680 @default.
- W3187441469 hasConceptScore W3187441469C197534660 @default.
- W3187441469 hasConceptScore W3187441469C198826908 @default.
- W3187441469 hasConceptScore W3187441469C204787440 @default.